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Titolo:
IDENTIFICATION OF HURTHLE CELL TUMOR BY SINGLE-INJECTION, DOUBLE-PHASE SCINTIGRAPHY WITH TECHNETIUM-99M-SESTAMIBI
Autore:
VATTIMO A; BERTELLI P; CINTORINO M; BURRONI L; VOLTERRANI D; VELLA A;
Indirizzi:
UNIV SIENA,LE SCOTTE HOSP,NUCL MED UNIT,VIALE BRACCI I-53100 SIENA ITALY UNIV SIENA,NUCL MED UNIT I-53100 SIENA ITALY UNIV SIENA,INST PATHOL I-53100 SIENA ITALY
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 5, volume: 36, anno: 1995,
pagine: 778 - 782
SICI:
0161-5505(1995)36:5<778:IOHCTB>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; COLD THYROID-NODULES; METHOXY ISOBUTYL ISONITRILE; FINE-NEEDLE ASPIRATION; GLAND; CARCINOMA; TL-201; CANCER; MITOCHONDRIAL; MANAGEMENT;
Keywords:
HURTHLE CELL TUMORS; THYROID NODULES; TECHNETIUM-99M-SESTAMIBI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A. Vattimo et al., "IDENTIFICATION OF HURTHLE CELL TUMOR BY SINGLE-INJECTION, DOUBLE-PHASE SCINTIGRAPHY WITH TECHNETIUM-99M-SESTAMIBI", The Journal of nuclear medicine, 36(5), 1995, pp. 778-782

Abstract

Early and late (double-phase) scintigraphy with Tc-99m-MIBI was used in a comparative study of the scintigraphic aspects of Hurthle cell tumors and other thyroid tumors. Methods: Single-injection, dual-phase (15-30 min and 3-4 hr) thyroid scintigraphy with Tc-99m-sestamibi (MIBI) was performed on 41 patients who displayed a cold nodule on previousTc-99m scintigraphy. Visual scoring of nodular uptake was done to compare thyroidal and background tracer uptake. In addition, the nodular-to-thyroid (NTT) uptake ratio in the early and late images and the washout rate from the nodule (WON) and thyroidal tissue (WOT) were measured. Cytologic results were obtained for all patients; histopathologic results were obtained for the 20 patients who had surgery. Results: Ineight patients (Group A), the nodule displayed intense and persistentuptake of MIBI (NTT = 1.77 +/- 0.46 and 3.20 +/- 1.37; WON = 17.2% +/- 6.3%; WOT = 24.6% +/- 7.5%); histopathology revealed Hurthle cell tumors (two carcinomas and three adenomas) in five surgical patients. In15 patients (Group B), the nodule displayed intense uptake in the early image with fading activity in the late image (NTT = 1.45 +/- 0.54 and 0.84 +/- 0.30; WON = 30.0% +/- 7.3%; WOT = 24.5% +/- 6.8%); histopathology revealed a colloid nodule (n = 1), papillary carcinoma (n = 4)and follicular carcinoma (n = 5) in 10 surgical patients. In the remaining 18 patients (Group C), the nodule was cold and late images were not acquired. Histopathology revealed colloid nodules (n = 2) and follicular adenoma (n = 3) in five surgical patients. Conclusion: Single-injection, dual-phase MIBI scintigraphy of the thyroid can identify Hurthle cell tumors because these tumors have intense, persistent tracer uptake in contrast to other thyroid tumors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 22:25:35