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Titolo:
THE DIVERSITY OF T-CELL RECEPTOR REPERTOIRE OF PERIPHERAL CD4(+) LYMPHOCYTES IN LEC MUTANT RATS
Autore:
MURAMATSU Y; AGUI T; SAKAI T; YAMADA T; MATSUMOTO K;
Indirizzi:
UNIV TOKUSHIMA,SCH MED,INST ANIM EXPERIMENTAT,KURAMOTO 3 TOKUSHIMA 770 JAPAN UNIV TOKUSHIMA,SCH MED,INST ANIM EXPERIMENTAT TOKUSHIMA 770 JAPAN NAGOYA CITY UNIV,SCH MED,INST EXPTL ANIM SCI NAGOYA AICHI 467 JAPAN
Titolo Testata:
Immunology letters
fascicolo: 3, volume: 45, anno: 1995,
pagine: 173 - 177
SICI:
0165-2478(1995)45:3<173:TDOTRR>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; LEWIS RATS; MATURATIONAL ARREST; BONE-MARROW; BETA-CHAINS; NUDE-MICE; THYMOCYTES; ALPHA; EXPRESSION; SEQUENCES;
Keywords:
T-CELL RECEPTOR REPERTOIRE; T-CELL MATURATION; HELPER T-CELL DEFICIENCY; (LEC RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
Y. Muramatsu et al., "THE DIVERSITY OF T-CELL RECEPTOR REPERTOIRE OF PERIPHERAL CD4(+) LYMPHOCYTES IN LEC MUTANT RATS", Immunology letters, 45(3), 1995, pp. 173-177

Abstract

A novel mutant strain of rats, LEG, exhibits an arrest of T-cell maturation from CD4(+)CD8(+) to CD4(+)CD8(-) but not to CD4(-)CD8(+) cellsin the thymus. Nevertheless, CD4(+)T cells arise in lymph nodes of LEC rats, implying extrathymic T-cell maturation. We analyzed the variable (V) and junctional region diversity of T-cell receptor (TCR) beta-chains in this population, since several reports have provided evidencethat extrathymically matured T cells exhibit a biased expression of the TCR repertoire. CD4(+) T cells in LEC rat lymph nodes exhibited a polymorphic V beta gene expression pattern. However, biased V beta geneexpression was not identified in peripheral CD4(+) T cells of LEC rats when compared with V beta gene expression in their thymocytes. Furthermore, junctional regions of TCR beta chains exhibited a vast diversity created by non-germline-encoded nucleotide (N nucleotide) additions. These results indicate that peripheral CD4(+) T cells in LEC rats possess a vast diversity in the TCR repertoire as do thymocytes of the same rat, suggesting that they derive from the thymus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:44:52