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Titolo:
THE USE OF GLUCOCORTICOIDS IN ACUTE LYMPHOBLASTIC-LEUKEMIA OF CHILDHOOD - MOLECULAR, CELLULAR, AND CLINICAL CONSIDERATIONS
Autore:
GAYNON PS; LUSTIG RH;
Indirizzi:
UNIV WISCONSIN HOSP,DEPT PEDIAT,DIV HEMATOL ONCOL,ROOM K4-430 CSC,600HIGHLAND AVE MADISON WI 53792 UNIV WISCONSIN HOSP,DEPT PEDIAT,DIV DIABET & ENDOCRINOL MADISON WI 53792
Titolo Testata:
Journal of pediatric hematology/oncology
fascicolo: 1, volume: 17, anno: 1995,
pagine: 1 - 12
SICI:
1077-4114(1995)17:1<1:TUOGIA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS ENDONUCLEASE ACTIVATION; UNFAVORABLE PRESENTING FEATURES; ACUTE LYMPHOCYTIC-LEUKEMIA; PRIMARY BRAIN-TUMORS; C-MYC; DNA FRAGMENTATION; GENE-EXPRESSION; LYMPHOID-CELLS; MESSENGER-RNA; DRUG RESISTANCE;
Keywords:
GLUCOCORTICOIDS; PREDNISONE; DEXAMETHASONE; LEUKEMIA; GLUCOCORTICOID RECEPTOR; ONCOGENES; APOPTOSIS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
141
Recensione:
Indirizzi per estratti:
Citazione:
P.S. Gaynon e R.H. Lustig, "THE USE OF GLUCOCORTICOIDS IN ACUTE LYMPHOBLASTIC-LEUKEMIA OF CHILDHOOD - MOLECULAR, CELLULAR, AND CLINICAL CONSIDERATIONS", Journal of pediatric hematology/oncology, 17(1), 1995, pp. 1-12

Abstract

Glucocorticoids have been included in almost all treatment regimens for childhood acute lymphoblastic leukemia for decades. However, optimal agents, doses, and/or schedules have yet to be defined despite extensive clinical application. New data on the pharmacokinetics, pharmacodynamics, and molecular mechanisms of action of glucocorticoids have suggested alternative approaches in ALL. These suggest that prolonged, i.e. 28 day, glucocorticoid therapy may be unnecessary as exposure to glucocorticoid induces down-regulation of glucocorticoid receptors. Dexamethasone may be superior to prednisone in conventional equi-effective doses. Blast sensitivity to glucocorticoids correlates closely with sensitivity to other, putatively non-cross-resisting agents and with outcome after multi-agent therapy, suggesting overlapping mechanisms ofaction, and focusing attention on the determinants of the threshold for apoptosis. Increasing success in the treatment of childhood acute lymphoblastic leukemia has led to increasing awareness of avascular necrosis of bone as a potentially disabling sequela of glucocorticoid therapy, especially in adolescent and young adult patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 04:14:54