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Titolo:
ADRENOMEDULLIN STIMULATES CAMP ACCUMULATION AND INHIBITS ATRIAL-NATRIURETIC-PEPTIDE GENE-EXPRESSION IN CARDIOMYOCYTES
Autore:
SATO A; CANNY BJ; AUTELITANO DJ;
Indirizzi:
BAKER MED RES INST,MOL PHYSIOL LAB,POB 348 PRAHRAN VIC 3181 AUSTRALIA BAKER MED RES INST,MOL PHYSIOL LAB PRAHRAN VIC 3181 AUSTRALIA MONASH UNIV,DEPT PHYSIOL CLAYTON VIC 3168 AUSTRALIA
Titolo Testata:
Biochemical and biophysical research communications
fascicolo: 2, volume: 230, anno: 1997,
pagine: 311 - 314
SICI:
0006-291X(1997)230:2<311:ASCAAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; HYPOTENSIVE PEPTIDE; RAT ADRENOMEDULLIN; SECRETION; CLONING; CDNA; PRECURSOR; FORSKOLIN; MYOCYTES; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
A. Sato et al., "ADRENOMEDULLIN STIMULATES CAMP ACCUMULATION AND INHIBITS ATRIAL-NATRIURETIC-PEPTIDE GENE-EXPRESSION IN CARDIOMYOCYTES", Biochemical and biophysical research communications, 230(2), 1997, pp. 311-314

Abstract

Adrenomedullin (ADM) is a novel vasodilating and natriuretic peptide which may play an important role in cardiovascular regulation. In neonatal cardiomyocyte cultures we have shown that ADM leads to dose-dependent increases in cAMP accumulation and subsequent inhibition of atrial natriuretic peptide (ANP) gene expression and secretion, Forskolin-mediated elevation of intracellular cAMP levels led to a qualitatively similar inhibitory effect on both ANP gene expression and secretion. These data show that ADM has direct effects on expression of ANP in thecardiomyocyte by a mechanism that may involve the activation of adenylate cyclase, lending further support to the hypothesis that ADM may act in vivo as an important endocrine or paracrine modulator of cardiovascular function. (C) 1997 Academic Press

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:51:48