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Titolo:
EFFICACY OF TUMOR-INFILTRATING LYMPHOCYTES IN THE TREATMENT OF HEPATIC METASTASES ARISING FROM TRANSGENIC INTRAOCULAR TUMORS IN MICE
Autore:
MA D; NIEDERKORN JY;
Indirizzi:
UNIV TEXAS,SW MED CTR,DEPT OPHTHALMOL,5323 HARRY HINES BLVD DALLAS TX75235 UNIV TEXAS,SW MED CTR,DEPT OPHTHALMOL DALLAS TX 75235
Titolo Testata:
Investigative ophthalmology & visual science
fascicolo: 6, volume: 36, anno: 1995,
pagine: 1067 - 1075
SICI:
0146-0404(1995)36:6<1067:EOTLIT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVEAL MALIGNANT-MELANOMA; RECOMBINANT INTERLEUKIN-2; ADOPTIVE IMMUNOTHERAPY; CHOROIDAL MELANOMA; ANTITUMOR-ACTIVITY; ANTERIOR-CHAMBER; NUDE-MICE; CANCER; IMMUNE; CELLS;
Keywords:
TUMOR-INFILTRATING LYMPHOCYTES; UVEAL MELANOMA; LIVER; METASTASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
D. Ma e J.Y. Niederkorn, "EFFICACY OF TUMOR-INFILTRATING LYMPHOCYTES IN THE TREATMENT OF HEPATIC METASTASES ARISING FROM TRANSGENIC INTRAOCULAR TUMORS IN MICE", Investigative ophthalmology & visual science, 36(6), 1995, pp. 1067-1075

Abstract

Purpose. The purpose of this study was to determine if tumor-infiltrating lymphocytes (TIL) isolated from transgenic intraocular tumors were capable of preventing the development of spontaneous hepatic metastases. Methods. Tumor-infiltrating lymphocytes were isolated from intraocular tumors in immuno-competent mice and were examined for cytolytic activity in vitro. The antigenic phenotypes of the TIL were determinedby in situ immunohistology. Cultured TIL were transferred adoptively to immunoincompetent, intraocular, tumor-bearing recipients to determine the efficacy of TIL in preventing spontaneous liver metastases. Results. Cultured TIL displayed remarkable cytolytic activity in vitro and antimetastatic properties after adoptive transfer into immunoincompetent, athymic nude mice and anti-CD4/CD8-treated euthymic FVB/N mice. Hepatic metastases developed in only 2 of 10 athymic nude mice that subsequently received TIL, whereas metastases developed in all 10 control mice. Similar results were found in anti-CD4/CD8-treated FVB/N mice. Hepatic metastases did not develop in any of the 10 mice treated withTIL, whereas extensive metastatic foci developed in all 10 untreated FVB/N control mice. The efficacy of TIL therapy was manifested also bysignificant prolongation of host survival times. Conclusions. Tumor-infiltrating lymphocytes isolated from intraocular tumors can be expanded in vitro and can exert antimetastatic effects in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 08:25:12