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Titolo:
PHOSPHORYLATION SWITCHES SPECIFIC FOR THE CARDIAC ISOFORM OF MYOSIN BINDING PROTEIN-C - A MODULATOR OF CARDIAC CONTRACTION
Autore:
GAUTEL M; ZUFFARDI O; FREIBURG A; LABEIT S;
Indirizzi:
EUROPEAN MOLEC BIOL LAB,MEYERHOFSTR 1 D-69117 HEIDELBERG GERMANY UNIV PAVIA PAVIA ITALY
Titolo Testata:
EMBO journal
fascicolo: 9, volume: 14, anno: 1995,
pagine: 1952 - 1960
SICI:
0261-4189(1995)14:9<1952:PSSFTC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; CHICKEN SKELETAL-MUSCLE; LIGHT CHAIN KINASE; IMMUNOGLOBULIN SUPERFAMILY; MYBP-C; IMMUNOELECTRON MICROSCOPY; MONOCLONAL-ANTIBODIES; MYOFIBRILLAR PROTEIN; X-PROTEIN; H-PROTEIN;
Keywords:
CARDIAC MUSCLE; FAMILIAL HYPERTROPHIC CARDIOMYOPATHY; MYOSIN BINDING PROTEIN; PROTEIN PHOSPHORYLATION; TITIN LIGAND;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
M. Gautel et al., "PHOSPHORYLATION SWITCHES SPECIFIC FOR THE CARDIAC ISOFORM OF MYOSIN BINDING PROTEIN-C - A MODULATOR OF CARDIAC CONTRACTION", EMBO journal, 14(9), 1995, pp. 1952-1960

Abstract

Cardiac myosin binding protein-C (cardiac MYBP-C, cardiac C protein) belongs to a family of proteins implicated in both regulatory and structural functions of striated muscle. For the cardiac isoform, regulatory phosphorylation in vivo by cAMP-dependent protein kinase (PKA) uponadrenergic stimulation is linked to modulation of cardiac contraction. The sequence of human cardiac MyBP-C now reveals regulatory motifs specific for this isoform. Site-directed mutagenesis identifies a LAGGGRRIS loop in the N-terminal region of cardiac MyBP-C as the key substrate site for phosphorylation by both PKA and a calmodulin-dependent protein kinase associated with the native protein. Phosphorylation of two further sites by PKA is induced by phosphorylation of this isoform-specific site. This phosphorylation switch can be mimicked by aspartic acid instead of phosphoserine. Cardiac MyBP-C is therefore specifically equipped with sensors for adrenergic regulation of cardiac contraction, possibly implicating cardiac MyBP-C in cardiac disease. The gene coding for cardiac MYBP-C has been assigned to the chromosomal location11p11.2 in humans, and is therefore in a region of physical linkage to subsets of familial hypertrophic cardiomyopathy (FHC). This makes cardiac MyBP-C a candidate gene for chromosome 11-associated FHC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:41:38