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Titolo:
MECHANISM OF INTESTINAL-ABSORPTION - EFFECT OF CLONIDINE ON RABBIT ILEAL VILLUS AND CRYPT CELLS
Autore:
SUNDARAM U;
Indirizzi:
YALE UNIV,SCH MED,DEPT MED NEW HAVEN CT 06510
Titolo Testata:
The Journal of clinical investigation
fascicolo: 5, volume: 95, anno: 1995,
pagine: 2187 - 2194
SICI:
0021-9738(1995)95:5<2187:MOI-EO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BICARBONATE SECRETION; ILEUM; TRANSPORT; SODIUM; PH; STIMULATION; EXCHANGE;
Keywords:
INTESTINAL ABSORPTION AND SECRETION; REGULATION OF SECRETION; BICARBONATE SECRETION; INTESTINAL ABSORPTOGOGUES; INTESTINAL ELECTROLYTE TRANSPORT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
U. Sundaram, "MECHANISM OF INTESTINAL-ABSORPTION - EFFECT OF CLONIDINE ON RABBIT ILEAL VILLUS AND CRYPT CELLS", The Journal of clinical investigation, 95(5), 1995, pp. 2187-2194

Abstract

In intact tissues studies, intestinal absorptogogues stimulate NaCl absorption that occurs via the dual operation of Na:H and Cl:HCO3 exchanges on the brush border membrane (BBM) of villus cells, To determine the cellular mechanism of action of an intestinal absorptogogue, the effect of clonidine was determined on Na:H and Cl:HCO3 exchange in rabbit ileal villus and crypt cells. Using 2,7-bis(carboxyethyl)-5,6-carboxy-fluorescein we have previously shown that recovery from an acid load occurs via Na:H exchange, whereas recovery from an alkaline load occurs via Cl:HCO3 exchange in both cells. In villus cells, the rate of recovery from a propionate-induced alkaline load was not altered by clonidine. However, clonidine stimulated recovery from an acid load induced by NH4Cl, Na removal, or amiloride. These data suggest that clonidine stimulates Na:H exchange in villus cells. In crypt cells, the rate of recovery from a propionate-induced alkaline load was also not altered by clonidine. However, in crypt cells, unlike the villus cells, clonidine inhibited recovery from an acid load induced by NH4Cl, Na removal, or amiloride. These data suggest that clonidine inhibits Na:H exchange in crypt cells. Stimulation of Na:H exchange on the BBM of villuscells would be expected to stimulate coupled NaCl absorption (which occurs by coupling of Na:H and Cl:HCO3 exchange). Inhibition of Na:H incrypt cells, known to be present only on the basolateral membrane, will acidify the cell and may inhibit Cl:HCO3 exchange on the BBM, resulting in the inhibition of HCO3 secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:23:41