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Titolo:
POTENT ANTIVIRAL ACTIVITY OF AN ANTISENSE OLIGONUCLEOTIDE COMPLEMENTARY TO THE INTRON-EXON BOUNDARY OF HUMAN CYTOMEGALOVIRUS GENES UL36 ANDUL37
Autore:
PARI GS; FIELD AK; SMITH JA;
Indirizzi:
HYBRIDON INC,1 INNOVAT DR WORCESTER MA 01605
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 5, volume: 39, anno: 1995,
pagine: 1157 - 1161
SICI:
0066-4804(1995)39:5<1157:PAAOAA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN IMMUNODEFICIENCY VIRUS; DEPENDENT DNA-SYNTHESIS; IMMEDIATE-EARLY REGION; TRANSIENT COMPLEMENTATION; TYPE-2 GROWTH; EXPRESSION; REPLICATION; OLIGODEOXYNUCLEOTIDES; IDENTIFICATION; GANCICLOVIR;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
G.S. Pari et al., "POTENT ANTIVIRAL ACTIVITY OF AN ANTISENSE OLIGONUCLEOTIDE COMPLEMENTARY TO THE INTRON-EXON BOUNDARY OF HUMAN CYTOMEGALOVIRUS GENES UL36 ANDUL37", Antimicrobial agents and chemotherapy, 39(5), 1995, pp. 1157-1161

Abstract

An antisense phosphorothioate oligonucleotide complementary to the intron-exon boundary of human cytomegalovirus genes UL36 and UL37 (UL36ANTI) reduced the yield of infectious virus by 99% and inhibited human cytomegalovirus DNA replication at a concentration of 0.08 mu M. In addition, oligonucleotides with base substitutions which resulted in base pair mismatches showed lesser degrees of activity, indicating a sequence-specific antisense mechanism. UL36ANTI was also shown to inhibit DNA replication of ganciclovir-resistant strains and human cytomegalovirus clinical isolates.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 13:57:46