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Titolo:
MOLECULAR-BIOLOGY AND PHARMACOLOGY OF CLONED OPIOID RECEPTORS
Autore:
KNAPP RJ; MALATYNSKA E; COLLINS N; FANG L; WANG JY; HRUBY VJ; ROESKE WR; YAMAMURA HI;
Indirizzi:
UNIV ARIZONA,COLL MED,DEPT PHARMACOL TUCSON AZ 85724 UNIV ARIZONA,COLL MED,DEPT PHARMACOL TUCSON AZ 85724 UNIV ARIZONA,DEPT MED TUCSON AZ 85724 UNIV ARIZONA,DEPT PSYCHIAT TUCSON AZ 85724 UNIV ARIZONA,DEPT CHEM TUCSON AZ 85724 UNIV ARIZONA,DEPT BIOCHEM TUCSON AZ 85724 UNIV ARIZONA,PROGRAM NEUROSCI TUCSON AZ 85724
Titolo Testata:
The FASEB journal
fascicolo: 7, volume: 9, anno: 1995,
pagine: 516 - 525
SICI:
0892-6638(1995)9:7<516:MAPOCO>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NALORPHINE-LIKE DRUGS; CHRONIC SPINAL DOG; RAT-BRAIN; MU-OPIATE; FUNCTIONAL EXPRESSION; AGONIST BINDING; MORPHINE-LIKE; MOUSE-BRAIN; CLONING; SPECIFICITY;
Keywords:
ENDORPHIN RECEPTORS; G-PROTEIN; ADENYLYL CYCLASE; CAMP FORMATION; CDNA; CLONING; EXPRESSION; ANTISENSE OLIGONUCLEOTIDES; SITE-DIRECTED MUTAGENESIS; MOLECULAR MODELING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
65
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Knapp et al., "MOLECULAR-BIOLOGY AND PHARMACOLOGY OF CLONED OPIOID RECEPTORS", The FASEB journal, 9(7), 1995, pp. 516-525

Abstract

The cloning and expression of DNA for the three major opioid receptortypes (mu, delta, and kappa) present new research opportunities for the characterization of opioid drugs and their interactions with these receptors. Genomic and cDNA clones for opioid receptors exist for several animal species including mouse, rat, guinea pig, and human. These include clones for all three human opioid receptor types. The receptorproteins consist of about 400 amino acids and have the characteristicseven transmembrane domain structure of G-protein-coupled receptors. There is about 60% amino acid identity between opioid receptor types and about 90% identity between a receptor type cloned from different animal species. Ah opioid receptor types mediate the inhibition of adenylyl cyclase in response to agonist binding. Radioligand binding and functional studies using the cloned receptors tend to support current conclusions on opioid drug receptor selectivity and activity. Investigations of opioid receptor chimeras and single amino acid mutants are providing information on the ligand recognition sites of these receptors and essential support for the development of computational opioid receptor models. A molecular model of the human delta opioid receptor is included in this review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 22:04:17