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Titolo:
EFFECT OF SIMVASTATIN ON LP(A) CONCENTRATIONS
Autore:
HAFFNER S; ORCHARD T; STEIN E; SCHMIDT D; LABELLE P;
Indirizzi:
MERCK & CO INC,WP 39-154,SUMNEYTOWN PIKE W POINT PA 19486 MERCK & CO INC W POINT PA 19486 UNIV TEXAS,HLTH SCI CTR,DEPT MED,DIV CLIN EPIDEMIOL SAN ANTONIO TX 78284 UNIV PITTSBURGH,SCH PUBL HLTH,DEPT EPIDEMIOL PITTSBURGH PA 15260 MED RES LABS CINCINNATI OH 00000 MED COLL WISCONSIN,DEPT MED MILWAUKEE WI 53226
Titolo Testata:
Clinical cardiology
fascicolo: 5, volume: 18, anno: 1995,
pagine: 261 - 267
SICI:
0160-9289(1995)18:5<261:EOSOLC>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; DENSITY LIPOPROTEIN CHOLESTEROL; FAMILIAL HYPERCHOLESTEROLEMIA; PLASMA; MICROALBUMINURIA; LOVASTATIN; REDUCTION; RISK; STANDARDIZATION; CHOLESTYRAMINE;
Keywords:
SIMVASTATIN; LP(A); LOW-DENSITY CHOLESTEROL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
S. Haffner et al., "EFFECT OF SIMVASTATIN ON LP(A) CONCENTRATIONS", Clinical cardiology, 18(5), 1995, pp. 261-267

Abstract

The effect of HMG-CoA reductase inhibitors on Lp(a) concentrations iscontroversial, with some studies showing an increase and others showing no effect on Lp(a) concentrations. Many of these studies have been limited by small sample size and the lack of a prospective design. We evaluated the effect of four treatments: (1) placebo, (2) simvastatin 10 mg PO QPM, (3) simvastatin 20 mg PO QAM, and (4) simvastatin 20 mg PO QPM on Lp(a) concentrations in a prospective, randomized, controlled clinical trial of 24 weeks in 343 subjects in 28 clinical sites in the United States. Simvastatin was not associated with a change in Lp(a) concentrations relative to placebo. These results were not affected by controlling for race, initial Lp(a) level, or urinary albumin excretion. Simvastatin significantly reduced low-density lipoprotein (LDL) cholesterol levels (10 mg PO QPM: -27.6%; 20 mg PO QAM: -28.1%; and 20mg PO QPM: -34.3%, all p<0.001). It was concluded that in a large, randomized, controlled trial, simvastatin does not affect Lp(a) levels but markedly lowers LDL cholesterol levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 20:01:36