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Titolo:
DEOXYTHYMIDINE KINASE IN THE TUMOR-CELLS AND SERUM OF PATIENTS WITH NON-HODGKIN LYMPHOMAS
Autore:
REHN S; GRONOWITZ JS; KALLANDER C; SUNDSTROM C; GLIMELIUS B;
Indirizzi:
UNIV UPPSALA,AKAD SJUKHUSET,DEPT ONCOL S-75185 UPPSALA SWEDEN UNIV UPPSALA,CTR BIOMED,REPLICAT ENZYMOL RES UNIT S-75123 UPPSALA SWEDEN UNIV UPPSALA,AKAD SJUKHUSET,DEPT PATHOL S-75185 UPPSALA SWEDEN
Titolo Testata:
British Journal of Cancer
fascicolo: 5, volume: 71, anno: 1995,
pagine: 1099 - 1105
SICI:
0007-0920(1995)71:5<1099:DKITTA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE; PROGNOSTIC RELEVANCE; BIOCHEMICAL MARKERS; BREAST-CANCER; PROLIFERATIVE ACTIVITY; MULTIVARIATE-ANALYSIS; FLOW-CYTOMETRY; LUNG-CANCER; CLASSIFICATION; DISEASE;
Keywords:
NON-HODGKIN LYMPHOMA; DEOXYTHYMIDINE KINASE; CELL PROLIFERATION; TUMOR VOLUME;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
S. Rehn et al., "DEOXYTHYMIDINE KINASE IN THE TUMOR-CELLS AND SERUM OF PATIENTS WITH NON-HODGKIN LYMPHOMAS", British Journal of Cancer, 71(5), 1995, pp. 1099-1105

Abstract

The levels of deoxythymidine kinase in tumour cells (C-TK) and in serum (S-TK) were investigated and the tumour volume calculated in 89 patients with non-Hodgkin lymphoma (NHL), in order to ascertain the importance of C-TK and tumour burden as regards the S-TK levels. Among all patients, a correlation was seen between S-TK and tumour volume but not between S-TK and C-TK. However, within different tumour volume categories (small, medium-sized and large), there was a correlation betweenS-TK and C-TK. Multiple regression analysis supported this notion. C-TK correlated with the proliferation-associated parameters, S-phase fraction and mitotic index. As already known, S-TK was found to have a strong prognostic value. C-TK and tumour burden were also of prognosticvalue. In multivariate analyses, C-TK and tumour volume did not provide prognostic information in addition to S-TK, whereas, in the absenceof S-TK, C-TK and tumour volume did provide additional information. It is concluded that the serum level of TK depends on both the tumour burden and the tumour cell proliferation rate. Based upon estimations of S-TK in patients assessed shortly after chemotherapy, we also suggest that S-TK reflects the number of proliferating cells that have died during the period immediately before sampling.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:44:01