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Titolo:
MITOCHONDRIAL BIOENERGETICS IS AFFECTED BY THE HERBICIDE PARAQUAT
Autore:
PALMEIRA CM; MORENO AJ; MADEIRA VMC;
Indirizzi:
UNIV COIMBRA,DEPT ZOOL P-3049 COIMBRA PORTUGAL UNIV COIMBRA,DEPT BIOCHEM P-3049 COIMBRA PORTUGAL
Titolo Testata:
Biochimica et biophysica acta. Bioenergetics
fascicolo: 2, volume: 1229, anno: 1995,
pagine: 187 - 192
SICI:
0005-2728(1995)1229:2<187:MBIABT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-LIVER MITOCHONDRIA; LIPID-PEROXIDATION; OXIDATIVE-PHOSPHORYLATION; SUPEROXIDE-DISMUTASE; MAMMALIAN-CELLS; TOXICITY; INVIVO; OVERPRODUCTION; HEPATOCYTES; INHIBITION;
Keywords:
PARAQUAT; MITOCHONDRION; HERBICIDE TOXICITY; SUPEROXIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
C.M. Palmeira et al., "MITOCHONDRIAL BIOENERGETICS IS AFFECTED BY THE HERBICIDE PARAQUAT", Biochimica et biophysica acta. Bioenergetics, 1229(2), 1995, pp. 187-192

Abstract

The potential toxicity of the herbicide paraquat (1,1-dimethyl-4,4'-bipyridylium dichloride) was tested in bioenergetic functions of isolated rat liver mitochondria. Paraquat increases the rate of State 4 respiration, doubling at 10 mM, indicating uncoupling effects. Additionally, State 3 respiration is depressed by about 15%, at 10 mM paraquat, whereas uncoupled respiration in the presence of CCCP is depressed by about 30%. Furthermore, paraquat partially inhibits the ATPase activitythrough a direct effect on this enzyme complex. However, at high concentrations (5-10 mM), the ATPase activity is stimulated, probably as consequence of the described uncoupling effect. Depression of respiratory activity is mediated through partial inhibitions of mitochondrial complexes III and IV. Paraquat depresses Delta Psi as a function of herbicide concentration. In addition, the depolarization induced by ADP is decreased and repolarization is biphasic suggesting a double effect. Repolarization resumes at a level consistently higher than the initial level before ADP addition, for paraquat concentrations up to 10 mM. This particular effect is clear at 1 mM paraquat and tends to fade outwith increasing concentrations of the herbicide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 01:40:36