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Titolo:
APOPTOSIS IN HUMAN ACUTE MYOCARDIAL-INFARCTION
Autore:
SARASTE A; PULKKI K; KALLAJOKI M; HENRIKSEN K; PARVINEN M; VOIPIOPULKKI LM;
Indirizzi:
UNIV TURKU,DEPT MED,KIINAMYLLYNKATU 4-8 FIN-20520 TURKU FINLAND UNIV TURKU,DEPT MED FIN-20520 TURKU FINLAND UNIV TURKU,DEPT ANAT FIN-20520 TURKU FINLAND UNIV TURKU,DEPT CLIN CHEM FIN-20520 TURKU FINLAND UNIV TURKU,DEPT PATHOL FIN-20520 TURKU FINLAND
Titolo Testata:
Circulation
fascicolo: 2, volume: 95, anno: 1997,
pagine: 320 - 323
SICI:
0009-7322(1997)95:2<320:AIHAM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
DNA FRAGMENTATION; CARDIOMYOCYTES;
Keywords:
APOPTOSIS; MYOCARDIAL INFARCTION; REPERFUSION; ISCHEMIA; THROMBOLYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
A. Saraste et al., "APOPTOSIS IN HUMAN ACUTE MYOCARDIAL-INFARCTION", Circulation, 95(2), 1997, pp. 320-323

Abstract

Background After reopening of the infarct-related coronary artery, cardiomyocytes continue to die Juring reperfusion. The mechanisms of cell death have been subject to debate. We studied whether an apoptotic type of cell death occurs in human acute myocardial infarction (AMI). Methods and Results We studied myocardial samples of right patients whodied of AMI and had patent infarct-related arteries at autopsy. Six of the patients had received initially successful thrombolysis. Extensive formation of DNA strand breaks, the typical biochemical feature of apoptosis, was detected with the use of the in situ DNA end-labeling method. Apoptotic cardiomyocytes were observed particularly in the border zones of histologically infarcted myocardium, whereas very few apoptotic cells were present in the remote noninfarcted myocardium. Internucleosomal fragmentation was confirmed by agarose gel electrophoresis of DNA isolated from the representative myocardial areas. Conclusions This study provides evidence that in addition to overt necrosis, a subset of myocytes undergo apoptosis during ischemia-reperfusion injury. Apoptosis may provide a new target for cardioprotection during evolving AMI in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:39:05