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Titolo:
GABA AND GLYCINE IN THE CENTRAL AUDITORY-SYSTEM OF THE MOUSTACHE BAT - STRUCTURAL SUBSTRATES FOR INHIBITORY NEURONAL ORGANIZATION
Autore:
WINER JA; LARUE DT; POLLAK GD;
Indirizzi:
UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,DIV NEUROBIOL,ROOM 289 LIFE SCI ADDIT BERKELEY CA 94720 UNIV TEXAS,DEPT ZOOL AUSTIN TX 78712
Titolo Testata:
Journal of comparative neurology
fascicolo: 3, volume: 355, anno: 1995,
pagine: 317 - 353
SICI:
0021-9967(1995)355:3<317:GAGITC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPERIOR OLIVARY COMPLEX; MEDIAL GENICULATE-BODY; GLUTAMIC-ACID DECARBOXYLASE; COMBINATION-SENSITIVE NEURONS; POSTEROVENTRAL COCHLEAR NUCLEUS; INFERIOR COLLICULUS NEURONS; THALAMIC RETICULAR NUCLEUS; HUMAN CEREBRAL-CORTEX; MOUSE-BRAIN SLICE; IMMUNOREACTIVE NEURONS;
Keywords:
INHIBITION; AXON TERMINALS; LOCAL CIRCUITS; INHIBITORY PROJECTIONS; DISINHIBITION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
148
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Winer et al., "GABA AND GLYCINE IN THE CENTRAL AUDITORY-SYSTEM OF THE MOUSTACHE BAT - STRUCTURAL SUBSTRATES FOR INHIBITORY NEURONAL ORGANIZATION", Journal of comparative neurology, 355(3), 1995, pp. 317-353

Abstract

The distribution and morphology of neurons and axonal endings (puncta) immunostained with antibodies to gamma-aminobutyric acid (GABA) and glycine (Gly) were analyzed in auditory brainstem, thalamic, and cortical centers in the mustache bat. The goals of the study were (1) to compare and contrast the location of GABAergic and glycinergic neurons and puncta, (2) to determine whether nuclei containing immunoreactive neurons likewise have a similar concentration of puncta, (3) to assess the uniformity of immunostaining within a nucleus and to consider regional differences that were related to or independent of cytoarchitecture, and (4) to compare the patterns recognized in this bat with those in other mammals. There are nine major conclusions. (1) Glycinergic immunostaining is most pronounced in the hindbrain. (2) In the forebrain, GABA alone is present. (3) Some nuclei have GABAergic or glycinergicneurons exclusively; a few have neither. (4) Although there is sometimes a close relationship between the relative number of immunopositiveneurons and the density of the puncta, just as often there is no particular correlation between them; this reflects the fact that many GABAergic and glycinergic neurons project beyond their nucleus of origin. (5) Even nuclei devoid of or with few GABAergic or glycinergic neuronscontain relatively abundant numbers of puncta; some neurons receive axosomatic terminals of each type. (6) In a few nuclei there are physiological subregions with specific local patterns of immunostaining. (7)The patterns of immunostaining resemble those in other mammals; the principal exceptions are in nuclei that, in the bat, are hypertrophied (such as those of the lateral lemniscus) and in the medial geniculate body. (8) Cellular colocalization of GABA and Gly is specific to only a few nuclei. (9) GABA and glutamic acid decarboxylase (GAD) immunostaining have virtually identical distributions in each nucleus. Several implications follow. First, the arrangements of GABA and Gly in the central auditory system represent all possible patterns, ranging from mutually exclusive to overlapping within a nucleus to convergence of both types of synaptic endings on single neurons. Second, although both transmitters are present in the hindbrain, glycine appears to be dominant, and it is often associated with circuitry in which precise temporal control of aspects of neuronal discharge is critical. Third, the auditory system, especially at or below the level of the midbrain, contains significant numbers of GABAergic or glycinergic projection. neurons. The latter feature distinguishes it from the central visual and somatic sensory pathways. (C) 1995 Wiley-Liss, Inc.

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Documento generato il 05/12/20 alle ore 13:55:04