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Titolo:
AMPHETAMINE, COCAINE, AND DIZOCILPINE ENHANCE PERFORMANCE ON A LEVER-RELEASE, CONDITIONED AVOIDANCE-RESPONSE TASK IN RATS
Autore:
WHITE IM; CHRISTENSEN JR; FLORY GS; MILLER DW; REBEC GV;
Indirizzi:
INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47405 INDIANA UNIV,DEPT PSYCHOL,PROGRAM NEURAL SCI BLOOMINGTON IN 47405
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 118, anno: 1995,
pagine: 324 - 331
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-DOPAMINE INTERACTIONS; NMDA ANTAGONIST MK-801; REACTION-TIME; ANTIPSYCHOTIC-DRUGS; MOVEMENT INITIATION; LOCOMOTOR-ACTIVITY; BRAIN DOPAMINE; PARKINSONS-DISEASE; NUCLEUS-ACCUMBENS; BASAL GANGLIA;
Keywords:
AMPHETAMINE; COCAINE; CONDITIONED AVOIDANCE RESPONSE TASK; DIZOCILPINE; HALOPERIDOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
I.M. White et al., "AMPHETAMINE, COCAINE, AND DIZOCILPINE ENHANCE PERFORMANCE ON A LEVER-RELEASE, CONDITIONED AVOIDANCE-RESPONSE TASK IN RATS", Psychopharmacology, 118(3), 1995, pp. 324-331

Abstract

A lever-release version of the conditioned avoidance response (CAR) task was used to assess the behavioral effects of several psychomotor stimulants in rats. The indirect dopamine agonists, d-amphetamine (0.1 and 0.25 mg/kg) and cocaine (7.5 and 15 mg/kg), enhanced performance on this task. Both drugs increased percent avoidance responses and decreased avoidance latency. A higher dose of amphetamine (0.5 mg/kg) alsodecreased avoidance latency but failed to improve percent avoidance. Similar effects were seen at low (0.01 and 0.025 mg/kg) and high (0.05mg/kg) doses of dizocilpine (MK-801), a stimulant that acts as a noncompetitive antagonist of N-methyl-d-aspartate (NMDA) glutamate receptors. When combined with haloperidol (0.1 mg/kg), a dopamine antagonist,amphetamine (0.25 mg/kg) and dizocilpine (0.025 mg/kg) had differential effects on the lever-release CAR task. Thus, amphetamine-haloperidol was significantly better than haloperidol alone on percent avoidancebut not on avoidance latency, whereas dizocilpine-haloperidol had theopposite effect: significantly better than haloperidol alone on avoidance latency but not on percent avoidance. Taken together, these results provide further support for dopaminergic mechanisms in CAR performance but suggest an opposing glutamatergic influence.

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Documento generato il 27/01/20 alle ore 16:59:08