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Titolo:
DEXAMETHASONE INHIBITS OZONE-INDUCED GENE-EXPRESSION OF MACROPHAGE INFLAMMATORY PROTEIN-2 IN RAT LUNG
Autore:
HADDAD EB; SALMON M; SUN J; LIU S; DAS A; ADCOCK I; BARNES PJ; CHUNG KF;
Indirizzi:
NATL HEART & LUNG INST,DEPT THORAC MED,DOVEHOUSE ST LONDON SW3 6LY ENGLAND NATL HEART & LUNG INST,DEPT THORAC MED LONDON SW3 6LY ENGLAND
Titolo Testata:
FEBS letters
fascicolo: 3, volume: 363, anno: 1995,
pagine: 285 - 288
SICI:
0014-5793(1995)363:3<285:DIOGOM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AIRWAY HYPERRESPONSIVENESS; MESSENGER-RNA; EXPOSURE; FAMILY; NEUTROPHIL; CYTOKINES; REACTIVITY; CLONING; HUMANS; INJURY;
Keywords:
OZONE; RAT LUNG; INFLAMMATION; NORTHERN BLOT; MIP-2 MESSENGER-RNA; DEXAMETHASONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
E.B. Haddad et al., "DEXAMETHASONE INHIBITS OZONE-INDUCED GENE-EXPRESSION OF MACROPHAGE INFLAMMATORY PROTEIN-2 IN RAT LUNG", FEBS letters, 363(3), 1995, pp. 285-288

Abstract

To address the potential role of the chemokine macrophage inflammatory protein-2 (MIP-2) in airway inflammation, we examined,whether MIP-2 may play a role in ozone-induced neutrophilic inflammation of airways and its modulation by dexamethasone in rat lung. Following ozone exposure, MIP-2 mRNA expression in the lung peaked at 2 h after exposure and slowly declined thereafter, Dexamethasone suppressed ozone-induced MIP-2 mRNA expression and neutrophil accumulation in the lung, We suggest that the MIP-2 mRNA induction may switch on the neutrophilic influxobserved in this model of lung inflammation, Furthermore, the MIP-2 expression is regulated by dexamethasone which may represent one of themechanisms by which glucocorticoids exert their potent anti-inflammatory properties.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 18:38:50