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Titolo:
COMBINATION OF HIGHLY PURIFIED HUMAN-LEUKOCYTE INTERFERON-ALPHA AND 13-CIS-RETINOIC ACID FOR THE TREATMENT OF METASTATIC MELANOMA
Autore:
FIERLBECK G; SCHREINER T; RASSNER G;
Indirizzi:
UNIV TUBINGEN,DEPT DERMATOL,LIEBERMEISTERSTR 25 D-72076 TUBINGEN GERMANY
Titolo Testata:
Cancer immunology and immunotherapy
fascicolo: 3, volume: 40, anno: 1995,
pagine: 157 - 164
SICI:
0340-7004(1995)40:3<157:COHPHI>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADVANCED MALIGNANT-MELANOMA; PHASE-II TRIAL; SQUAMOUS-CELL CARCINOMA; PULSE THERAPY SCHEDULE; RETINOIC ACID; LYMPHOBLASTOID INTERFERON; SYSTEMIC CHEMOTHERAPY; CANCER-PATIENTS; ONCOLOGY GROUP; EXPRESSION;
Keywords:
MELANOMA; 13-CIS-RETINOIC ACID; INTERFERON ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
G. Fierlbeck et al., "COMBINATION OF HIGHLY PURIFIED HUMAN-LEUKOCYTE INTERFERON-ALPHA AND 13-CIS-RETINOIC ACID FOR THE TREATMENT OF METASTATIC MELANOMA", Cancer immunology and immunotherapy, 40(3), 1995, pp. 157-164

Abstract

The effect of 13-cis-retinoic acid and highly purified human leukocyte interferon alpha (Alphaferon) therapy for metastatic melanoma was studied. A group of 17 patients with disseminated malignant melanoma were treated over a 6-month period. They received 60 mg 13-cis-retinoic acid/day continuously and ten cycles of interferon alpha (IFN alpha). IFN was administered by subcutaneous injection, at a daily dose of 6 x 10(6) IU Alphaferon. The 5-day treatment period was followed by an IFN-free interval of 2 weeks. We were able to observe an overall responserate of 30% with 12% complete responses (2 out of 17 patients). Sitesof response included the skin, lung, liver and lymph nodes. All responses have now lasted over 6 months. Therapy was generally well tolerated and could be performed on an outpatient basis. Side-effects of thiscombination therapy did not exceed the established side-effects of the two substances. We also studied 2'-5'-oligoadenylate synthetase, beta 2-microglobulin and neopterin levels during the whole treatment course. All patients were within the normal range before treatment and a sharp rise occurred during each IFN cycle. The maximum being observed 24 h after the third injection. This indicates a high biological activity of IFN alpha administered cyclicly during the whole treatment course. This finding also corresponds well with the absence of neutralizingantibodies before and after the whole treatment period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 16:58:12