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Titolo:
CIRCULATING INHIBINS AND ACTIVIN-A DURING GNRH-ANALOG DOWN-REGULATIONAND OVARIAN HYPERSTIMULATION WITH RECOMBINANT FSH FOR IN-VITRO FERTILIZATION-EMBRYO TRANSFER
Autore:
LOCKWOOD GM; MUTTUKRISHNA S; GROOME NP; KNIGHT PG; LEDGER WL;
Indirizzi:
JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND OXFORD BROOKES UNIV,SCH BIOL & MOL SCI OXFORD OX3 0BP ENGLAND UNIV READING,SCH ANIM MICROBIAL SCI READING RG6 2AJ BERKS ENGLAND
Titolo Testata:
Clinical endocrinology
fascicolo: 6, volume: 45, anno: 1996,
pagine: 741 - 748
SICI:
0300-0664(1996)45:6<741:CIAADG>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
BOVINE FOLLICULAR-FLUID; HUMAN MENSTRUAL-CYCLE; INVITRO FERTILIZATION; ALPHA-SUBUNIT; IMMUNOACTIVE INHIBIN; STIMULATING-HORMONE; DIMERIC INHIBIN; CORPUS-LUTEUM; SERUM INHIBIN; GONADOTROPIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
G.M. Lockwood et al., "CIRCULATING INHIBINS AND ACTIVIN-A DURING GNRH-ANALOG DOWN-REGULATIONAND OVARIAN HYPERSTIMULATION WITH RECOMBINANT FSH FOR IN-VITRO FERTILIZATION-EMBRYO TRANSFER", Clinical endocrinology, 45(6), 1996, pp. 741-748

Abstract

OBJECTIVE We have investigated serial changes in plasma concentrations of inhibin A, inhibin B, pro alpha C and activin A in women undergoing stimulation with recombinant FSH in 'long-protocol' down-regulated cycles of IVF treatment. DESIGN Blood samples were collected during the entire IVF treatment cycle at points coinciding with the early follicular phase of the cycle preceding treatment, pituitary down-regulation, stimulation with recombinant FSH, ovulatory triggering, and the luteal phase of the cycle. In patients who achieved conception, blood samples were also taken during the first 2 weeks of pregnancy. All samples were analysed for inhibin A, inhibin B, pro alpha C, activin A and oestradiol. PATIENTS Fifteen women with normal ovarian function undergoing IVF treatment with tubal factor, mild endometriosis or idiopathic infertility. RESULTS During pituitary desensitization, both inhibin A and inhibin B were significantly (P < 0.001, P = 0.002, respectively) reduced whereas levels of pro alpha C and activin A were largely unaltered. Levels of both inhibins rose markedly (P < 0.01) during FSH stimulation and a further rise in inhibin A was detected on the day after ovulatory trigger. Levels of both inhibin A and inhibin a then fell during and after oocyte pickup and continued to fall during the luteal phase. Activin A levels rose less markedly during gonadotrophin stimulation. Statistical analysis showed a high degree of correlation betweenthe number of follicles (> 10 mm) and serum inhibin A (r = 0.65, P < 0.01) and pro alpha C (r = 0.65, P < 0.01) concentrations during the late follicular phase. CONCLUSIONS These results indicate that ovarian production of dimeric inhibin A and B are gonadotrophin dependent, whereas activin A may have a significant gonadotrophin independent or extra-gonadal source. Inhibin A and pro alpha C may be useful markers formonitoring the effects of gonadotrophin stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 12:32:46