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Titolo:
LONG-TERM PULMONARY SEQUELAE IN CHILDREN WITH CONGENITAL DIAPHRAGMATIC-HERNIA
Autore:
IJSSELSTIJN H; TIBBOEL D; HOP WJC; MOLENAAR JC; DEJONGSTE JC;
Indirizzi:
SOPHIA CHILDRENS UNIV HOSP,DEPT PEDIAT,DIV PEDIAT RESP MED,DR MOLEWATERPLEIN 60 NL-3015 GJ ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT PEDIAT,DIV PEDIAT RESP MED ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT PEDIAT SURG NL-3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM,DEPT EPIDEMIOL & BIOSTAT NL-3000 DR ROTTERDAM NETHERLANDS UNIV HOSP,SOPHIA CHILDRENS HOSP ROTTERDAM NETHERLANDS
Titolo Testata:
American journal of respiratory and critical care medicine
fascicolo: 1, volume: 155, anno: 1997,
pagine: 174 - 180
SICI:
1073-449X(1997)155:1<174:LPSICW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
WORKING PARTY STANDARDIZATION; EUROPEAN RESPIRATORY SOCIETY; LOW-BIRTH-WEIGHT; LUNG-FUNCTION; BRONCHOPULMONARY DYSPLASIA; AIRWAY RESPONSIVENESS; SODIUM METABISULFITE; OFFICIAL STATEMENT; REPAIR; SURVIVORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H. Ijsselstijn et al., "LONG-TERM PULMONARY SEQUELAE IN CHILDREN WITH CONGENITAL DIAPHRAGMATIC-HERNIA", American journal of respiratory and critical care medicine, 155(1), 1997, pp. 174-180

Abstract

Neonates with congenital diaphragmatic hernia (CDH) often suffer fromrespiratory insufficiency due to lung hypoplasia and pulmonary hypertension. Artificial ventilation is frequently required, and this leads to a high incidence of bronchopulmonary dysplasia. Long-term follow-upstudies have shown persisting airway obstruction. To evaluate the long-term pulmonary sequelae in CDH, we studied 40 CDH patients of age 7 to 18 yr (median 11.7 yr) and 65 age-matched controls without CDH and lung hypoplasia who underwent similar neonatal treatment. Mild airway obstruction was found in both groups with more peripheral airway obstruction in CDH patients than in control subjects. Both groups had normal TLC and single-breath carbon monoxide diffusion capacity (DL(CO)). CDH patients had increased residual volume (RV) and RV/TLC compared with controls. Increased airway responsiveness to methacholine (MCH) was common but bronchoconstriction to inhaled metabisulfite (MBS) was rareboth in CDH and control subjects. We conclude that this group of CDH patients has minor residual lung function impairment. Mild airway obstruction and increased airway responsiveness to inhaled MCH but not to MBS suggest that structural changes in distal airways are involved andnot autonomic nerve dysfunction. Both artificial ventilation in the neonatal period and residual rung hypoplasia seem important determinants of persistent lung function abnormalities in CDH patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:58:19