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Titolo:
SPATIAL STRUCTURE OF 2-LOCUS GENOTYPES UNDER ISOLATION BY DISTANCE
Autore:
EPPERSON BK;
Indirizzi:
MICHIGAN STATE UNIV,DEPT FORESTRY E LANSING MI 48824
Titolo Testata:
Genetics
fascicolo: 1, volume: 140, anno: 1995,
pagine: 365 - 375
SICI:
0016-6731(1995)140:1<365:SSO2GU>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTO-CORRELATION ANALYSIS; AUTOCORRELATION ANALYSIS; POPULATION-GENETICS; IMPATIENS-CAPENSIS; SELECTION; POLYMORPHISMS; INFERENCES; PATTERNS; BIOLOGY; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
B.K. Epperson, "SPATIAL STRUCTURE OF 2-LOCUS GENOTYPES UNDER ISOLATION BY DISTANCE", Genetics, 140(1), 1995, pp. 365-375

Abstract

Extensive Monte Carlo simulations are conducted of spatial distributions of two-locus genotypes in large, continuous populations under isolation by distance models. The results show that substantial patches ofdouble homozygotes are present in the spatial structures, even when loci are unlinked. The stochastic spread of identical two-locus genotypes largely outpowers the tendency for recombination to decouple patterns for separate loci. A spatial patch is a large area containing mostly one double homozygous genotype in a highly contiguous constellation. This patch structure is reflected in high positive spatial autocorrelations and large excesses of pairs, or joins, of identical double homozygotes at short-to-intermediate distances of spatial separation. Although spatial patches of double homozygotes are the dominant spatial feature, and the major contributors to overall high levels of autocorrelations among two-locus genotypes, other substantial features include areas of concentrations of identical genotypes heterozygous at only onelocus. One implication of the patch structure is the presence of highlevels of linkage disequilibrium, caused by isolation by distance even for unlinked loci, at some spatial scales; yet the disequilibrium inthe large total populations is near 0. Thus linkage disequilibrium produced by isolation by distance is highly dependent on spatial scale. Another implication is that high degrees of spatial structuring and autocorrelations are produced for genetic variation controlling quantitative traits, at least when the number of loci is relatively small, under a wide range of situations, even if the trait is selectively neutral. The significance of the results to field studies is also examined.

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Documento generato il 01/12/20 alle ore 22:21:01