Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ORGANOPHOSPHORUS-INDUCED DELAYED NEUROTOXICITY - A COMPARATIVE-STUDY OF THE EFFECTS OF TRI-ORTHO-TOLYL PHOSPHATE AND TRIPHENYL PHOSPHITE ONTHE CENTRAL-NERVOUS-SYSTEM OF THE JAPANESE-QUAIL
Autore:
VARGHESE RG; BURSIAN SJ; TOBIAS C; TANAKA D;
Indirizzi:
MICHIGAN STATE UNIV,DEPT ANAT,A514 E FEE HALL E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT ANAT E LANSING MI 48824 MICHIGAN STATE UNIV,DEPT ANIM SCI E LANSING MI 48824 MICHIGAN STATE UNIV,INST ENVIRONM TOXICOL E LANSING MI 48824
Titolo Testata:
Neurotoxicology
fascicolo: 1, volume: 16, anno: 1995,
pagine: 45 - 54
SICI:
0161-813X(1995)16:1<45:ODN-AC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESTERASE INHIBITION; CRESYL PHOSPHATE; RATS; NEUROPATHY; DAMAGE; INITIATION; MODEL; HEN;
Keywords:
TRI-ORTHO-TOLYL PHOSPHATE; TRIPHENYL PHOSPHITE; NEUROPATHOLOGY; NEUROPATHY TARGET ESTERASE; ORGANOPHOSPHORUS-INDUCED DELAYED NEUROTOXICITY; CENTRAL NERVOUS SYSTEM; JAPANESE QUAIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Varghese et al., "ORGANOPHOSPHORUS-INDUCED DELAYED NEUROTOXICITY - A COMPARATIVE-STUDY OF THE EFFECTS OF TRI-ORTHO-TOLYL PHOSPHATE AND TRIPHENYL PHOSPHITE ONTHE CENTRAL-NERVOUS-SYSTEM OF THE JAPANESE-QUAIL", Neurotoxicology, 16(1), 1995, pp. 45-54

Abstract

The neurotoxic effects of single oral doses of tri-ortho-tolyl phosphate (TOTP) (500 mg/kg body weight) or single subcutaneous injections of triphenyl phosphite (TPP) (62.5-500mg/kg body weight) were in vestigated in the Japanese quail (Coturnix coturnix japonica). Oral doses ofTOTP resulted in no detectable clinical signs while injections of TPPresulted in mild ataxia to severe paralysis depending upon the dosagelevel. At 24hr postdosing, whole-brain activity of neuropathy target esterase (NTE) was inhibited by 90% in birds exposed to TOTP and by 11-87% in birds injected with TPP. Oral doses of TOTP resulted in only sparse Fink-Heimer silver-impregnated degeneration in the white matter of the cerebellum with no degeneration noted in any other region of the brain. Injections of TPP resulted in widespread degeneration in large numbers of brainstem nuclei and tracts and in all cerebellar foliae and deep nuclei. These results indicate that the Japanese quail responds differentially to exposure to TOTP and TPP. Oral doses of TOTP do not result in clinical signs or in significant amounts of degeneration in the brain even though NTE activity is inhibited by 90%. In contrast, injections of TPP at higher dosage levels yield severe clinical signs, widespread axonal and terminal degeneration in the CNS, and significant inhibition of NTE activity. This sharp dichotomy in relative sensitivity to TOTP and TPP in the Japanese quail suggests that each compound may have its own unique effect on CNS structure and function. In addition, the relationship between levels of NTE inhibition and the onset of clinical signs or neuropathology remains unclear. (C) 1995 IntoxPress, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 10:17:45