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Titolo:
REPEATED ECS DIFFERENTIALLY AFFECTS RAT-BRAIN 5-HT1A AND 5-HT2A RECEPTOR EXPRESSION
Autore:
BURNET PWJ; MEAD A; EASTWOOD SL; LACEY K; HARRISON PJ; SHARP T;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,DEPT PSYCHIAT,GIBSON BLDG,WOODSTOCK RD OXFORD OX2 6HE ENGLAND UNIV OXFORD,RADCLIFFE INFIRM,DEPT NEUROPATHOL OXFORD OX2 6HE ENGLAND UNIV OXFORD,RADCLIFFE INFIRM,DEPT CLIN PHARMACOL OXFORD OX2 6HE ENGLAND
Titolo Testata:
NeuroReport
fascicolo: 6, volume: 6, anno: 1995,
pagine: 901 - 904
SICI:
0959-4965(1995)6:6<901:REDAR5>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELECTROCONVULSIVE SHOCK; AUTORADIOGRAPHIC ANALYSIS; SEROTONIN-2 RECEPTORS; MESSENGER-RNA; FEMALE RATS; HIPPOCAMPUS; 8-OH-DPAT; NEURONS; DRUGS;
Keywords:
5-HT1A; 5-HT2A; HIPPOCAMPUS; ELECTROCONVULSIVE SHOCK; SEIZURE; MESSENGER-RNA; IN SITU HYBRIDIZATION; ANTIDEPRESSANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
P.W.J. Burnet et al., "REPEATED ECS DIFFERENTIALLY AFFECTS RAT-BRAIN 5-HT1A AND 5-HT2A RECEPTOR EXPRESSION", NeuroReport, 6(6), 1995, pp. 901-904

Abstract

WE investigated the effect of electroconvulsive shock (ECS), administered five times over 10 days, on 5-HT1A and 5-HT2A receptor mRNA and binding site densities in the rat brain using in situ hybridization histochemistry and quantitative autoradiography. ECS treatment increased 5-HT1A receptor mRNA abundance and binding site densities in the dentate gyrus, but decreased these parameters in the CA3c layer of the hippocampus. No changes in 5-HT1A receptor mRNA and binding sites occurredin other hippocampal subfields, neocortex or raphe nuclei. Repeated ECS was also found to increase 5-HT2A receptor binding site densities in the neocortex and this was accompanied by a non-significant increasein cortical 5-HT2A receptor mRNA abundance. Our study demonstrates that in the rat, repeated ECS produces anatomically and molecularly discrete effects on 5-HT1A and 5-HT2A receptor gene expression. These changes may be relevant to the therapeutic effect of repeated ECS in depression.

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Documento generato il 16/07/20 alle ore 19:42:51