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Titolo:
STUNNED MYOCARDIUM AND THE ATTENUATION OF STUNNING BY CALCIUM-ANTAGONISTS
Autore:
EHRING T; HEUSCH G;
Indirizzi:
UNIV GIESSEN KLINIKUM,ZENTRUM INNERE MED,PATHOPHYSIOL ABT,HUFELANDSTR55 D-45122 ESSEN GERMANY UNIV GIESSEN KLINIKUM,ZENTRUM INNERE MED,PATHOPHYSIOL ABT D-45122 ESSEN GERMANY
Titolo Testata:
The American journal of cardiology
fascicolo: 13, volume: 75, anno: 1995,
pagine: 61 - 67
SICI:
0002-9149(1995)75:13<61:SMATAO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
REGIONAL BLOOD-FLOW; FREE-RADICAL GENERATION; REPERFUSED CANINE MYOCARDIUM; LEFT-VENTRICULAR PERFORMANCE; CORONARY-ARTERY REPERFUSION; TRANS-LUMINAL ANGIOPLASTY; CONSCIOUS DOGS; CONTRACTILE FUNCTION; TIME COURSE; POSTEXTRASYSTOLIC POTENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
122
Recensione:
Indirizzi per estratti:
Citazione:
T. Ehring e G. Heusch, "STUNNED MYOCARDIUM AND THE ATTENUATION OF STUNNING BY CALCIUM-ANTAGONISTS", The American journal of cardiology, 75(13), 1995, pp. 61-67

Abstract

Myocardial ''stunning'' is characterized by a reversible postischemiccontractile dysfunction despite full restoration of blood flow. The underlying mechanisms are not clearly understood. inadequate energy supply and impaired sympathetic neurotransmission have been excluded. Potential mechanisms, which are not mutually exclusive, may include damage to membranes and enzymes by free radicals, an increase in free cytosolic calcium during ischemia and reperfusion, and a lower calcium sensitivity of myofibrils. The equally pronounced increases in regional contractility innormal and stunned myocardium during postextrasystolic potentiation and the infusion of calcium or the calcium-sensitizing agent AR-L-57, however, suggest an unchanged calcium sensitivity in reperfused myocardium. Pretreatment with calcium antagonists before ischemia attenuates myocardial stunning. This effect is probably related to alessened myocardial calcium overload during early ischemia. The potential benefit of treatment with calcium antagonists after reperfusion is established remains controversial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 20:11:28