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Titolo:
HYPERACTIVITY IN NEONATALLY DOPAMINE-LESIONED RATS REQUIRES RESIDUAL ACTIVITY IN MESOLIMBIC DOPAMINE NEURONS
Autore:
LUTHMAN J; LINDQVIST E; OGREN SO;
Indirizzi:
ASTRA ARCUS AB,PRECLIN RES & DEV,BEHAV & BIOCHEM PHARMACOL,BLDG 218 S-15185 SODERTALJE SWEDEN KAROLINSKA INST,DEPT NEUROSCI STOCKHOLM SWEDEN
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 51, anno: 1995,
pagine: 159 - 163
SICI:
0091-3057(1995)51:1<159:HINDRR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENYLATE-CYCLASE ACTIVITY; DEPLETING BRAIN-LESIONS; 6-HYDROXYDOPAMINE; TERMINALS; BEHAVIOR;
Keywords:
DOPAMINE; 6-HYDROXYDOPAMINE; NEONATAL; HYPERACTIVITY; ALPHA-METHYL-P-TYROSINE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
J. Luthman et al., "HYPERACTIVITY IN NEONATALLY DOPAMINE-LESIONED RATS REQUIRES RESIDUAL ACTIVITY IN MESOLIMBIC DOPAMINE NEURONS", Pharmacology, biochemistry and behavior, 51(1), 1995, pp. 159-163

Abstract

Neonatal destruction of mesencephalic dopamine (DA) neurons in rats through administration of 6-hydroxydopamine (6-OHDA; 75 mu g IC) leads to locomotor hyperactivity at adulthood. Treatment with the catecholamine synthesis inhibitor alpha-methyl-p-tyrosine (H44/68; 250 mg/kg) was shown to reduce the motor activity of neonatally 6-OHDA-lesioned rats to activity levels similar to controls. In both animal groups, DA and metabolite tissue levels decreased after the H44/68 treatment. However, the extent of the H44/68-induced DA decrease was less pronounced in the 6-OHDA-lesioned animals, with no change at all in the dorsal striatum. These results imply that residual activity in mesolimbic DA neurons is required for maintaining the hyperactivity seen after neonatal6-OHDA lesions, and that this hyperactivity is apparently mediated bypostsynaptic alterations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:16:07