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Titolo:
DIFFERENT LOCALIZATION OF ET(A) AND ET(B) RECEPTORS IN THE HYPERPLASTIC VASCULAR WALL
Autore:
AZUMA H; HAMASAKI H; SATO J; ISOTANI E; OBAYASHI S; MATSUBARA O;
Indirizzi:
TOKYO MED & DENT UNIV,INST MED & DENT ENGN,DEPT MED CHEM,CHIYODA KU,2-3-10 SURUGADAI TOKYO 101 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT NEUROSURG TOKYO 101 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT GYNECOL & OBSTET TOKYO 101 JAPAN TOKYO MED & DENT UNIV,FAC MED,DEPT PATHOL TOKYO 101 JAPAN
Titolo Testata:
Journal of cardiovascular pharmacology
fascicolo: 5, volume: 25, anno: 1995,
pagine: 802 - 809
SICI:
0160-2446(1995)25:5<802:DLOEAE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; ENDOTHELIN RECEPTOR; PHOSPHOINOSITIDE BREAKDOWN; CORONARY ANGIOPLASTY; DNA-SYNTHESIS; NITRIC-OXIDE; INHIBITION; ANTAGONIST; POTENT; IMMUNOREACTIVITY;
Keywords:
BALLOON ANGIOPLASTY; NEOINTIMA FORMATION; ET-1 RECEPTORS; ET-1[BIOTIN-LYS(9)]; BQ123; RO 46-2005;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
H. Azuma et al., "DIFFERENT LOCALIZATION OF ET(A) AND ET(B) RECEPTORS IN THE HYPERPLASTIC VASCULAR WALL", Journal of cardiovascular pharmacology, 25(5), 1995, pp. 802-809

Abstract

We investigated which subtypes of endothelin-1 (ET-1) receptors are involved in the pathogenesis of angioplasty-induced lesion formation inthe rabbit carotid artery. Four weeks after removing endothelial cells (EC), we noted a marked intimal hyperplasia. The B-max values for [I-125]ET-1 and [I-125]IRL1620 (an agonist for the ET(B) receptors) bindings were greater in the hyperplastic artery, without changes in K-d values. [I-125]ET-1 binding was completely inhibited by unlabeled ET-1 and Ro 46-2005, a mixed-type antagonist for the ET(A) and ET(B) receptors, but partially by BQ123, a selective antagonist for ET(A) receptors, and IRL1620. The [I-125]ET-1 binding sites not inhibited with BQ123were significantly increased in the hyperplastic artery. The binding study suggested the presence of non-ET(A)/non-ET(B) receptors. The rank order of the increasing ratio in the density of receptors was ET(B) > putative non-ET(A)/non-ET(B) > total ET-1 receptors > ET(A). The histochemical experiments with biotinylated ET-1 at lysine-9 side chain alone or in combination with unlabeled ET-1, BQ123, Ro 46-2005, or IRL1620, showed the ET(A) receptors to be localized mainly in the media, whereas the ET(B) receptors localized mainly in the neointima. These results suggest that the increased ET-1 receptors, especially ET(B) and/or putative non-ET(A)/non-ET(B), are closely related to the occurrenceof the intimal hyperplasia after endothelial removal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:26:44