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Titolo:
NERVE GROWTH-FACTOR RECEPTOR AND NEUROCHEMICAL MARKERS IN HUMAN ORAL-MUCOSA - AN IMMUNOHISTOCHEMICAL STUDY
Autore:
FANTINI F; GIANNETTI A; BENASSI L; CATTANEO V; MAGNONI C; PINCELLI C;
Indirizzi:
OSPED CIVILE VENEZIA,DIV DERMATOL I-30122 VENICE ITALY UNIV PAVIA,CHAIR PARODONTOL I-27100 PAVIA ITALY UNIV MODENA,INST DERMATOL I-41100 MODENA ITALY
Titolo Testata:
Dermatology
fascicolo: 3, volume: 190, anno: 1995,
pagine: 186 - 191
SICI:
1018-8665(1995)190:3<186:NGRANM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORY NEURONS; HUMAN KERATINOCYTES; HUMAN SKIN; EXPRESSION; RAT; INNERVATION; PEPTIDE; CELLS; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY;
Keywords:
NERVE GROWTH FACTOR RECEPTOR; NEUROPEPTIDES; ORAL MUCOSA; INNERVATION; IMMUNOFLUORESCENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
F. Fantini et al., "NERVE GROWTH-FACTOR RECEPTOR AND NEUROCHEMICAL MARKERS IN HUMAN ORAL-MUCOSA - AN IMMUNOHISTOCHEMICAL STUDY", Dermatology, 190(3), 1995, pp. 186-191

Abstract

Background: The innervation of the oral mucosa has so far been studied mainly by histochemical and ultrastructural techniques. Only few studies have investigated the presence of neural proteins and neurotransmitters in human gingival mucosa. Objective: The purpose of the presentstudy was to evaluate the presence and distribution of neural structural and transmitter proteins in different areas of normal human oral mucosa. Method: Indirect immunofluorescence was employed on specimens taken from different mucosal regions (gingiva, lips, gums, palate). Both structural (low-affinity nerve growth factor receptor, NGFr; proteingene product 9.5, PGP 9.5) and neuropeptide markers (substance P; calcitonin gene-related peptide; vasoactive intestinal peptide, neuropeptide Y) were used. Results: NGFr and PGP 9.5 intensely labelled both nerve fibres and selected epithelial cells, while neuropeptide immunoreactivity was scarcely expressed and exclusively localized in nerve fibres, Conclusion: Similarity in the distribution pattern and neurochemistry between oral and cutaneous innervation is apparent. Expression of NGFr could be relevant to the trophism of both the oral innervation and epithelium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:08:22