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Titolo:
MAINTENANCE OF PROTECTIVE IMMUNITY AGAINST MALARIA BY PERSISTENT HEPATIC PARASITES DERIVED FROM IRRADIATED SPOROZOITES
Autore:
SCHELLER LF; AZAD AF;
Indirizzi:
UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL BALTIMORE MD 21201 UNIV MARYLAND,SCH MED,DEPT MICROBIOL & IMMUNOL BALTIMORE MD 21201
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 9, volume: 92, anno: 1995,
pagine: 4066 - 4068
SICI:
0027-8424(1995)92:9<4066:MOPIAM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-BERGHEI SPOROZOITES; EFFICACY; LIVER; CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
L.F. Scheller e A.F. Azad, "MAINTENANCE OF PROTECTIVE IMMUNITY AGAINST MALARIA BY PERSISTENT HEPATIC PARASITES DERIVED FROM IRRADIATED SPOROZOITES", Proceedings of the National Academy of Sciences of the United Statesof America, 92(9), 1995, pp. 4066-4068

Abstract

Immunization of rodents and humans with irradiation-attenuated malaria sporozoites confers preerythrocytic stage-specific protective immunity to challenge infection, This immunity is directed against intrahepatic parasites and involves T cells and interferon gamma, which preventdevelopment of exoerythrocytic stages and subsequent blood infection. The present study was undertaken to determine how protective immunityis achieved after immunization of rodent hosts with irradiated Plasmodium berghei sporozoites. We present evidence that irradiated parasites persist in hepatocytes of rats and mice for up to 6 months after immunization. A relationship between the persistence of parasites and themaintenance of protective immunity was observed. Protective immunity was abrogated in irradiated-sporozoite-immunized rats following the application of chemotherapy to remove preexisting liver parasites. Additionally, protective immunity against sporozoite challenge was established in rats vaccinated with early and late hepatic stages of irradiated parasites, These results show that irradiation-attenuated sporozoites produce persistent intrahepatic stages in vivo necessary for the induction and maintenance of protective immunity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:13:22