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Titolo:
A MONOCLONAL-ANTIBODY MODULATES NEUTROPHIL ADHERENCE WHILE ENHANCING CELL MOTILITY
Autore:
OHTAKE K; TAKEI H; WATANABE T; SATO Y; YAMASHITA T; SUDO K; KUROKI M; CHIHARA J; SENDO F;
Indirizzi:
YAMAGATA UNIV,SCH MED,DEPT IMMUNOL & PARASITOL,2-2-2 IIDANISHI YAMAGATA 99023 JAPAN YAMAGATA UNIV,SCH MED,DEPT IMMUNOL & PARASITOL YAMAGATA 99023 JAPAN FUKUOKA UNIV,SCH MED,DEPT BIOCHEM TAKASAKI GUMMA 370 JAPAN AKITA UNIV,SCH MED,DEPT CLIN & LAB MED AKITA 010 JAPAN
Titolo Testata:
Microbiology and immunology
fascicolo: 1, volume: 41, anno: 1997,
pagine: 67 - 72
SICI:
0385-5600(1997)41:1<67:AMMNAW>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKOCYTE ADHESION MOLECULE-1; NECROSIS-FACTOR-ALPHA; CHEMOTACTIC FACTORS; ENDOTHELIAL-CELLS; INVITRO; CD18; PROTEINS; ANTIGEN; EXPRESSION; ACTIVATION;
Keywords:
LEUKOCYTE; ADHERENCE; MONOCLONAL ANTIBODY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K. Ohtake et al., "A MONOCLONAL-ANTIBODY MODULATES NEUTROPHIL ADHERENCE WHILE ENHANCING CELL MOTILITY", Microbiology and immunology, 41(1), 1997, pp. 67-72

Abstract

A monoclonal antibody (MoAb) to human neutrophils, designated 3H9, was established by screening for the inhibition of neutrophil adherence to plastic plates containing a medium supplemented with fetal calf serum (FCS medium), The antigen recognized by 3H9 was shown to be presenton human leukocytes and found at the highest levels on granulocytes, On Western blotting, 3H9 reacted with a molecule having a molecular weight of 80 kDa. When this MoAb was added at the same time as a neutrophil stimulant (fMLP), the inhibition of neutrophil adherence to plastic plates in the presence of FCS medium was observed after 60 min incubation. Furthermore, this MoAb enhanced not only fMLP-induced chemotaxis but random migration of neutrophils as well. The mechanisms of thesephenomena are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 15:52:29