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Titolo:
GENETIC DETERMINATION OF COAGULATION-FACTOR VIIC LEVELS AMONG HEALTHYMIDDLE-AGED WOMEN
Autore:
MEILAHN E; FERRELL R; KISS J; TEMPLE A; GREEN F; HUMPHRIES S; KULLER L;
Indirizzi:
UNIV LONDON LONDON SCH HYG & TROP MED,DEPT EPIDEMIOL & POPULAT SCI,KEPPEL ST LONDON WC1E 7HT ENGLAND UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL PITTSBURGH PA 00000 UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT HUMAN GENET PITTSBURGH PA 15261 UNIV COLL LONDON,SCH MED,RAYNE INST,DEPT MED LONDON W1N 8AA ENGLAND CENT BLOOD BANK PITTSBURGH,COAGULAT LABS PITTSBURGH PA 00000
Titolo Testata:
Thrombosis and haemostasis
fascicolo: 4, volume: 73, anno: 1995,
pagine: 623 - 625
SICI:
0340-6245(1995)73:4<623:GDOCVL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; RISK-FACTORS; MENOPAUSAL STATUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
E. Meilahn et al., "GENETIC DETERMINATION OF COAGULATION-FACTOR VIIC LEVELS AMONG HEALTHYMIDDLE-AGED WOMEN", Thrombosis and haemostasis, 73(4), 1995, pp. 623-625

Abstract

A recent study (1) reported variation among men in clotting factor VIIc levels is associated with a genetic polymorphism detected by the restriction enzyme Msp I. The present study determined the Msp I genotype (Arg(353), Gln(353) alleles) for 189 women (mean age 53) who were subjects in the Healthy Women Study, a population study of CHD risk factor change at menopause. Women with the Arg/Arg genotype (n = 147) had an 16% higher (geometric) mean FVIIc level than those with the Arg/Gln(n = 41) genotype (1.21 vs 1.04 U/ml, p<0.01), while the one subject with the Gln/Gln genotype had an FVIIc level of 1.00 U/ml. These results are consistent with those previously found in healthy men (I). In addition, women carrying the Gin allele did not exhibit the elevation in FVIIc with menopause and use of hormone therapy found among those with the Arg allele, suggesting that genotype may modify the observed rise in factor VIIc at menopause. Possibly because of the small sample size this interaction did not reach conventional levels of statistical significance. Results of multiple linear regression analyses controlling for age, hormone use, obesity, (In) triglyceride levels, and familyhistory of CHD found FVIIc levels to be significantly (p<0.001) related to genotype. Thus, genotype appears to be a major determinant of FVIIc levels among women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 09:37:22