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Titolo:
RESULTS OF 100 CASES OF PULSE-SPRAY THROMBOLYSIS FOR ACUTE AND SUBACUTE LEG ISCHEMIA
Autore:
ARMON MP; YUSUF SW; WHITAKER SC; GREGSON RHS; WENHAM PW; HOPKINSON BR;
Indirizzi:
UNIV NOTTINGHAM HOSP,DEPT VASC SURG,E FLOOR,W BLOCK NOTTINGHAM NG7 2UH ENGLAND UNIV NOTTINGHAM HOSP,DEPT RADIOL NOTTINGHAM NG7 2UH ENGLAND
Titolo Testata:
British Journal of Surgery
fascicolo: 1, volume: 84, anno: 1997,
pagine: 47 - 50
SICI:
0007-1323(1997)84:1<47:RO1COP>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN ACTIVATOR; PERIPHERAL THROMBOLYSIS; INTRAARTERIAL THROMBOLYSIS; ARTERIAL ISCHEMIA; THERAPY; STREPTOKINASE; OCCLUSIONS; EXPERIENCE; RISK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Armon et al., "RESULTS OF 100 CASES OF PULSE-SPRAY THROMBOLYSIS FOR ACUTE AND SUBACUTE LEG ISCHEMIA", British Journal of Surgery, 84(1), 1997, pp. 47-50

Abstract

Background Pulse-spray thrombolysis is a rapid technique for the treatment of limb ischaemia of recent onset. Early results have been published but the longer term results are not known. Methods This study consisted of a series of 100 legs with acute and subacute ischaemia treated using this method with a follow-up interval of up to 3 years, Eighty-three limbs were classified as Fontaine grade III or IV and 42 had asensory or motor deficit. Sixty-seven limbs were treated with pulse spray alone and 33 had an additional low-dose infusion. In 71 cases an additional catheter-directed intervention was required. Results Medianduration of lysis was 135 (range 35-1540) min and median dose of recombinant tissue plasminogen activator used was 18 (range 4-01) mg. Complete radiological patency was achieved in 79 limbs and the ankle:brachial pressure index improved from a median of 0 (range 0-0.8) to 0.8 (range 0-1.5) (P <0.0001). At 30 days ten patients had died, eight needed amputation and a further 11 had rethrombosed, Cumulative limb salvage rate at 30 months was 79 per cent (standard error 8) and the estimated cumulative patency rate for successful cases was 72 per cent (standard error 10). The incidence of major bleeding was 7 per cent and of minor bleeding 24 per cent. There were no haemorrhagic strokes but three thrombotic strokes occurred within 30 days of thrombolysis. Conclusion Pulse-spray thrombolysis achieves rapid and safe revascularization of acute and subacute leg ischaemia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 08:19:44