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Titolo:
PHORBOL DIACETATE DIFFERENTIALLY REGULATES THE N-METHYL-D-ASPARTATE (NMDA) AND NON-NMDA RECEPTOR-MEDIATED COMPONENTS OF THE RAT HIPPOCAMPALEXCITATORY POSTSYNAPTIC CURRENTS
Autore:
LOZOVAYA NA; KLEE MR;
Indirizzi:
MAX PLANCK INST BRAIN RES,DEPT NEUROPHYSIOL,DEUTSCHORDENSTR 46 D-60528 FRANKFURT GERMANY AA BOGOMOLETS PHYSIOL INST KIEV 252024 UKRAINE
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 189, anno: 1995,
pagine: 101 - 104
SICI:
0304-3940(1995)189:2<101:PDDRTN>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; LONG-TERM POTENTIATION; SYNAPTIC TRANSMISSION; CHANNELS; NEURONS; CALCIUM; MODULATION; MECHANISM; ESTERS; ENHANCEMENT;
Keywords:
PHORBOL ESTERS; HIPPOCAMPAL EXCITATORY POSTSYNAPTIC CURRENTS; PROTEIN KINASE C; H-7 N-METHYL-D-ASPARTATE (NMDA) NON-NMDA COMPONENTS RATIO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
N.A. Lozovaya e M.R. Klee, "PHORBOL DIACETATE DIFFERENTIALLY REGULATES THE N-METHYL-D-ASPARTATE (NMDA) AND NON-NMDA RECEPTOR-MEDIATED COMPONENTS OF THE RAT HIPPOCAMPALEXCITATORY POSTSYNAPTIC CURRENTS", Neuroscience letters, 189(2), 1995, pp. 101-104

Abstract

The effects of phorbol 12,13-diacetate (PDAc) on evoked excitatory transmission were studied in neurons of the CA1 area of hippocampal slices of rats, using whole-cell voltage clamp of pyramidal neurons in situ and stimulation of the Schaffer collaterals. The application of PDAc(10 mu M) increased the amplitude of the excitatory postsynaptic current (EPSC) and caused a lengthening of its decay, due to an increase in the contribution of the N-methyl-D-aspartate (NMDA) component to thetotal EPSC. The latter effect was depend upon the concentration of calcium in the extracellular medium, Experiments in which we separated the two components of the EPSCs by 6-cyano-7-nitroquinoxaline-2,3-dioneand by 2-amino-5-phosphonopentanoic acid also demonstrated a more pronounced increase in the NMDA receptor-mediated current under PDAc. Theeffects of PDAc were markedly attenuated by the extracellular application of the protein kinase C inhibitor H-7 (300 mu M), but not by intracellular perfusion with 20 mM of the same drug,

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 23:53:49