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Titolo:
REGIONAL BRAIN METABOLIC RESPONSE TO LORAZEPAM IN SUBJECTS AT RISK FOR ALCOHOLISM
Autore:
VOLKOW ND; WANG GJ; BEGLEITER H; HITZEMANN R; PAPPAS N; BURR G; PASCANI K; WONG C; FOWLER JS; WOLF AP;
Indirizzi:
BROOKHAVEN NATL LAB,DEPT MED,BLDG 490 UPTON NY 11973 VET ADM MED CTR NORTHPORT NY 00000 SUNY,DEPT PSYCHIAT BROOKLYN NY 00000 SUNY STONY BROOK,DEPT PSYCHIAT STONY BROOK NY 11794
Titolo Testata:
Alcoholism, clinical and experimental research
fascicolo: 2, volume: 19, anno: 1995,
pagine: 510 - 516
SICI:
0145-6008(1995)19:2<510:RBMRTL>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CHLORIDE CHANNEL COMPLEX; SHORT-SLEEP MICE; CHRONIC ETHANOL; LONG-SLEEP; RECEPTOR-BINDING; BODY SWAY; BENZODIAZEPINE RECEPTORS; GENETIC-DIFFERENCES; RO 15-4513;
Keywords:
BENZODIAZEPINES; POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE METABOLISM; ALCOHOLISM; CEREBELLUM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
78
Recensione:
Indirizzi per estratti:
Citazione:
N.D. Volkow et al., "REGIONAL BRAIN METABOLIC RESPONSE TO LORAZEPAM IN SUBJECTS AT RISK FOR ALCOHOLISM", Alcoholism, clinical and experimental research, 19(2), 1995, pp. 510-516

Abstract

The mechanisms underlying the blunted response to alcohol administration observed in subjects at risk for alcoholism are poorly understood and may involve GABA-benzodiazepine receptors. The purpose of this study was to investigate if subjects at risk for alcoholism had abnormalities in brain GABA-benzodiazepine receptor function, This study measured the effects of 30 mu g/kg (iv) of lorazepam, on regional brain glucose metabolism using positron emission tomography and 2-deoxy-2[F-18]fluoro-D-glucose in subjects with a positive family history for alcoholism (FP) (n = 12) and compared their response with that of subjects with a negative family history for alcoholism (FN) (n = 21). At baseline, FP subjects showed lower cerebellar metabolism than FN. Lorazepam decreased whole-brain glucose metabolism, and FP subjects showed a similar response to FN in cortical and subcortical regions, but FP showed ablunted response in cerebellum, Lorazepam-induced changes in cerebellar metabolism correlated with its motor effects. The decreased cerebellar baseline metabolism in FP as well as the blunted cerebellar response to lorazepam challenge may reflect disrupted activity of benzodiazepine-GABA receptors in cerebellum. These changes could account for thedecreased sensitivity to the motor effects of alcohol and benzodiazepines in FP subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:05:27