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Titolo:
DIISOPROPYL PHOSPHOROFLUORIDATE (DFP) TREATMENT ALTERS CALCIUM-ACTIVATED PROTEINASE ACTIVITY AND CYTOSKELETAL PROTEINS OF THE HEN SCIATIC-NERVE
Autore:
GUPTA RP; ABOUDONIA MB;
Indirizzi:
DUKE UNIV,MED CTR,DEPT PHARMACOL,POB 3813 DURHAM NC 27710 DUKE UNIV,MED CTR,DEPT PHARMACOL DURHAM NC 27710
Titolo Testata:
Brain research
fascicolo: 1, volume: 677, anno: 1995,
pagine: 162 - 166
SICI:
0006-8993(1995)677:1<162:DP(TAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED DELAYED NEUROTOXICITY; DEGENERATION;
Keywords:
DIISOPROPYL PHOSPHOROFLUORIDATE; HEN; INTERMEDIATE FILAMENT PROTEINS; CYTOSKELETAL PROTEINS; CANP; OPIDN;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R.P. Gupta e M.B. Aboudonia, "DIISOPROPYL PHOSPHOROFLUORIDATE (DFP) TREATMENT ALTERS CALCIUM-ACTIVATED PROTEINASE ACTIVITY AND CYTOSKELETAL PROTEINS OF THE HEN SCIATIC-NERVE", Brain research, 677(1), 1995, pp. 162-166

Abstract

Diisopropyl phosphorofluoridate (DFP) produces delayed neurotoxicity (OPIDN) in hens that is characterized by peripheral and central axonaldegeneration. DFP administration resulted in mCANP activity inhibition in sciatic nerve and significant decrease in total NF-H, phosphorylated NF-H, vimentin, GFAP, tubulin, and tau. The degradation of cytoskeletal proteins even in the presence of decreased CANP activity may be ascribed to the release of intracellular Ca2+, elevation of other proteinase activity, or modification of cytoskeletal proteins resulting intheir increased susceptibility in OPIDN.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:38:23