Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
COMPARATIVE EFFECTS OF AMITRIPTYLINE AND AMINEPTINE IN PATIENTS AFFECTED BY ANXIOUS DEPRESSION
Autore:
RAMPELLO L; NICOLETTI G; RAFFAELE R; DRAGO F;
Indirizzi:
UNIV CATANIA,POLICLIN,CATTEDRA NEUROFISIOPATOL,V A DORIA 6 I-95125 CATANIA ITALY UNIV CATANIA,SCH MED,INST NEUROL SCI CATANIA ITALY UNIV CATANIA,SCH MED,INST NEUROSURG CATANIA ITALY UNIV CATANIA,SCH MED,INST PHARMACOL I-95125 CATANIA ITALY
Titolo Testata:
Neuropsychobiology
fascicolo: 3, volume: 31, anno: 1995,
pagine: 130 - 134
SICI:
0302-282X(1995)31:3<130:CEOAAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIDEPRESSANT TREATMENT; RAT-BRAIN; DRUGS; SYNAPTOSOMES; BULBECTOMY; RECEPTORS; ANXIETY;
Keywords:
ANXIOUS DEPRESSION; AMITRIPTYLINE; AMINEPTINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
L. Rampello et al., "COMPARATIVE EFFECTS OF AMITRIPTYLINE AND AMINEPTINE IN PATIENTS AFFECTED BY ANXIOUS DEPRESSION", Neuropsychobiology, 31(3), 1995, pp. 130-134

Abstract

In a double-blind, placebo-controlled study, the therapeutic efficacyof two antidepressants with different neurochemical mechanisms of action, amitriptyline and amineptine, was investigated in patients affected by anxious depression. Sixty-six patients with the primary dignosisof major depression or bipolar affective disorder (DSM-III-R) and meeting additional operational clinical criteria such as anxiety, trepidation, restlessness, early and/or late insomnia, impulsivity, hostility, dysphoria, compulsivity, hyperperspiration, palpitation, pollakiuriaand phobias were included. They were randomly assigned to three groups (n = 22) and treated either with placebo, amitriptyline (up to 100 mg/day) or amineptine (up to 200 mg/day) for 6 weeks. Patients showed better response to amitriptyline, a preferential inhibitor of serotoninreuptake, than to amineptine, a selective inhibitor of dopamine reuptake. The present results suggest that alterations in serotonergic rather than dopaminergic transmission contribute to the pathophysiology ofanxious depression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:15:42