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Titolo:
EFFECT OF AGING ON URINARY-EXCRETION OF 19-NORALDOSTERONE AND 18,19-DIHYDROXYCORTICOSTERONE
Autore:
TAKEDA Y; MIYAMORI I; YONEDA T; IKI K; TAKEDA R;
Indirizzi:
KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 2 KANAZAWA ISHIKAWA 920 JAPAN
Titolo Testata:
Journal of steroid biochemistry and molecular biology
fascicolo: 4, volume: 52, anno: 1995,
pagine: 383 - 386
SICI:
0960-0760(1995)52:4<383:EOAOUO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALDOSTERONE-PRODUCING ADENOMA; BLOOD-PRESSURE; 19-NOR-DEOXYCORTICOSTERONE; 19-NOR-ALDOSTERONE; 18-HYDROXY-19-NORCORTICOSTERONE; AGE; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
Y. Takeda et al., "EFFECT OF AGING ON URINARY-EXCRETION OF 19-NORALDOSTERONE AND 18,19-DIHYDROXYCORTICOSTERONE", Journal of steroid biochemistry and molecular biology, 52(4), 1995, pp. 383-386

Abstract

19-Noraldosterone, recently shown to be produced in the human adrenalgland, possesses potent mineralocorticoid and hypertensinogenic activity. A possible precursor, 18,19-dihydroxycorticosterone, has been identified in human urine, with both steroids acutely regulated by the renin-angiotensin system. The secretion of aldosterone declines with advancing age. To elucidate the effect of aging on the urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone, we measured their urinary concentrations in 51 normotensive subjects aged 20-70 years. We observed significant negative correlations between age and the urinary excretion of 19-noraldosterone and 18,19-dihydroxycorticosterone (r = -0.69, r = -0.65, P < 0.05, respectively). Urinary and plasma aldosterone and PRA similarly decreased with aging. These results suggest that 19-noraldosterone may be chronically regulated in part by the renin-angiotensin system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 10:35:30