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Titolo:
EFFECT OF POLICOSANOL ON LIPOFUNDIN-INDUCED ATHEROSCLEROTIC LESIONS IN RATS
Autore:
NOA M; MAS R; DELAROSA MC; MAGRANER J;
Indirizzi:
NATL CTR SCI RES,HISTOL LAB,POB 6880 HAVANA CUBA
Titolo Testata:
Journal of Pharmacy and Pharmacology
fascicolo: 4, volume: 47, anno: 1995,
pagine: 289 - 291
SICI:
0022-3573(1995)47:4<289:EOPOLA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
M. Noa et al., "EFFECT OF POLICOSANOL ON LIPOFUNDIN-INDUCED ATHEROSCLEROTIC LESIONS IN RATS", Journal of Pharmacy and Pharmacology, 47(4), 1995, pp. 289-291

Abstract

Policosanol is a mixture of higher aliphatic alcohols isolated from sugar cane wax, showing cholesterol-lowering effects and preventing thedevelopment of lipofundin-induced lesions in New Zealand rabbits. This study was conducted to determine whether policosanol orally administered to rats also protects against the development of lipofundin-induced atherosclerotic lesions. Fifty four male Wistar rats were randomly distributed amongst a negative control group, a positive control groupintravenously injected with lipofundin for eight days, and four experimental groups also injected with lipofundin, but orally receiving policosanol at 0.5, 2.5, 5 and 25 mg kg(-1) respectively. Policosanol treatment was orally administered once-a-day for eight days, while control groups similarly received equivalent amounts of vehicle. A significant reduction of the atherosclerotic lesions in the treated animals wasobserved. It is concluded that policosanol has a protective effect onlipofundin-induced aortic lesions in Wistar rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/10/20 alle ore 01:45:25