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Titolo:
RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS AFTER IMMUNOTHERAPY FOR CANCER
Autore:
PARKER MG; ATKINS MB; UCCI AA; LEVEY AS;
Indirizzi:
LAHEY CLIN FDN,NEPHROL SECT,41 MALL RD BURLINGTON MA 01805 TUFTS UNIV NEW ENGLAND MED CTR,DIV NEPHROL BOSTON MA 02111 TUFTS UNIV,SCH MED,DEPT MED BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DIV HEMATOL ONCOL BOSTON MA 02111 TUFTS UNIV NEW ENGLAND MED CTR,DEPT PATHOL BOSTON MA 02111
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 10, volume: 5, anno: 1995,
pagine: 1740 - 1744
SICI:
1046-6673(1995)5:10<1740:RPGAIF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DOSE INTERLEUKIN-2; ACTIVATED KILLER-CELLS; RECOMBINANT INTERLEUKIN-2; NEPHROTIC SYNDROME; INTERSTITIAL NEPHRITIS; INTERFERON-ALPHA; RENAL-FUNCTION; THERAPY; HYPOTHYROIDISM; CARCINOMA;
Keywords:
PAUCI-IMMUNE GLOMERULONEPHRITIS; INTERLEUKIN-2; INTERFERON-ALPHA; CELLULAR IMMUNITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
M.G. Parker et al., "RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS AFTER IMMUNOTHERAPY FOR CANCER", Journal of the American Society of Nephrology, 5(10), 1995, pp. 1740-1744

Abstract

Cytokines have been used in experimental and standard protocols for immune enhancement for cancer. The combination of interleukin-2 and interferon-alpha 2 beta has been used in experimental protocols for metastatic renal cell carcinoma. A man who developed rapidly progressive renal failure after receiving this combination therapy is reported. A renal biopsy revealed a pauci-immune crescentic glomerulonephritis. Antineutrophil cytoplasmic antibodies and antiglomerular basement membraneantibodies were absent. The spectrum of renal disease and potentiallyrelated extrarenal manifestations associated with interleukin-2 and interferon-alpha are reviewed. A pathogenesis of altered cell-mediated immunity, consistent with abnormalities in extrarenal organs after immune enhancement, is proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:59:01