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Titolo:
REGULATION OF T-CELL-DEPENDENT AND T-CELL-INDEPENDENT IL-12 PRODUCTION BY THE 3 TH2-TYPE CYTOKINES IL-10, IL-6, AND IL-4
Autore:
TAKENAKA H; MARUO S; YAMAMOTO N; WYSOCKA M; ONO S; KOBAYASHI M; YAGITA H; OKUMURA K; HAMAOKA T; TRINCHIERI G; FUJIWARA H;
Indirizzi:
OSAKA UNIV,SCH MED,BIOMED RES CTR,2-2 YAMADA CHO SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,BIOMED RES CTR SUITA OSAKA 565 JAPAN UNIV PENN,SCH MED,WISTAR INST ANAT & BIOL PHILADELPHIA PA 19104 GENET INST INC CAMBRIDGE MA 00000 JUNTENDO UNIV,SCH MED TOKYO 113 JAPAN
Titolo Testata:
Journal of leukocyte biology
fascicolo: 1, volume: 61, anno: 1997,
pagine: 80 - 87
SICI:
0741-5400(1997)61:1<80:ROTATI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; INTERFERON-GAMMA-PRODUCTION; BLOOD MONONUCLEAR-CELLS; STIMULATORY FACTOR INTERLEUKIN-12; LYMPHOCYTE MATURATION FACTOR; IFN-GAMMA; TH1 CELLS; IMMUNOREGULATORY FUNCTIONS; IMMUNE-RESPONSES; GENE-EXPRESSION;
Keywords:
CD40 LIGAND; MACROPHAGES; DENDRITIC CELLS; INTERFERON-GAMMA; LIPOPOLYSACCHARIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
H. Takenaka et al., "REGULATION OF T-CELL-DEPENDENT AND T-CELL-INDEPENDENT IL-12 PRODUCTION BY THE 3 TH2-TYPE CYTOKINES IL-10, IL-6, AND IL-4", Journal of leukocyte biology, 61(1), 1997, pp. 80-87

Abstract

The production of IL-12 by macrophages/dendritic cells (M phi/DC) is mediated either by a T cell-dependent pathway that is induced primarily by the interaction of CD40 ligand (CD40L) on activated T cells with CD40 on IL-12-producing cells or by a T cell-independent pathway that is induced by bacteria or bacterial products and enhanced by interferon-gamma (IFN-gamma), In this study we investigated the ability of the Th2-type cytokines interleukin (IL) -10, IL-6, and IL-4 to modulate IL-12 production in M phi/DC induced through the two pathways, IL-12 production was induced in M phi/DC from normal mice by stimulation with the combination of IFN-gamma plus lipopolysaccharide (LPS) or Staphylococcus aureus Cowan I (a model for the T cell-independent pathway) or by co-culture with Chinese hamster ovary (CHO) cells transfected with the CD40L (a model for the T cell-dependent pathway), The effects of three Th2-type cytokines on IL-12 production by M phi/DC through the twopathways were examined, IL-10 inhibited IL-12 production induced through both pathways, although the inhibitory effect was more potent on the (IFN-gamma + LPS)-induced pathway,IL-6 inhibited only (LPS + IFN-gamma)-induced IL-12 production, The effect of IL-4 was particularly noteworthy: this cytokine inhibited(LPS + IFN-gamma)-induced IL-12 production, whereas it potentiated the production of IL-12 induced by CD40L. Regulation of IL-12 protein production by IL-10 and IL-4 was found tocorrespond to the levels of mRNA accumulation for the p40 and p35 IL-12 genes, whereas the presence of IL-6 during stimulation decreased IL-12 protein production without affecting steady-state mRNA levels, These results indicate that IL-12 production in M phi/DC induced through a T cell-dependent or -independent pathway is positively or negativelyregulated by particular cytokines at various control levels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:01:40