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Titolo:
IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF (ITAM), A UNIQUE MODULE LINKING ANTIGEN AND FC-RECEPTORS TO THEIR SIGNALING CASCADES
Autore:
ISAKOV N;
Indirizzi:
BEN GURION UNIV NEGEV,FAC HLTH SCI,DEPT MICROBIOL & IMMUNOL,POB 653 IL-84105 BEER SHEVA ISRAEL BEN GURION UNIV NEGEV,FAC HLTH SCI,CTR CANC RES IL-84105 BEER SHEVA ISRAEL
Titolo Testata:
Journal of leukocyte biology
fascicolo: 1, volume: 61, anno: 1997,
pagine: 6 - 16
SICI:
0741-5400(1997)61:1<6:ITAM(A>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL-RECEPTOR; BOVINE LEUKEMIA-VIRUS; EPSTEIN-BARR-VIRUS; SEVERE COMBINED IMMUNODEFICIENCY; PROTEIN-KINASE P56LCK; AMINO-TERMINAL DOMAIN; TANDEM SH2 DOMAINS; ZETA-CHAIN; IG-ALPHA; CYTOPLASMIC TAIL;
Keywords:
SIGNAL TRANSDUCTION; PROTEIN TYROSINE KINASE; TYROSINE PHOSPHORYLATION; LYMPHOCYTE ACTIVATION; SH2; SRC;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
123
Recensione:
Indirizzi per estratti:
Citazione:
N. Isakov, "IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF (ITAM), A UNIQUE MODULE LINKING ANTIGEN AND FC-RECEPTORS TO THEIR SIGNALING CASCADES", Journal of leukocyte biology, 61(1), 1997, pp. 6-16

Abstract

Signal transduction by the T cell and B cell antigen receptors and byreceptors for a variety of immunoglobulins' Fc region is strictly dependent on a receptor subunit cytoplasmic module termed immunoreceptor tyrosine-based activation motif (ITAM). This module exists in one or more copies in each of the receptor-associated signal-transducing molecules and it possesses two repeats of the consensus sequence Tyr-X-X-Leu/Ile spaced by six to eight amino acids. Receptor engagement is followed by a rapid and transient phosphorylation of tyrosine residues within their ITAMs, thereby creating temporary binding sites for Src homology 2 (SH2)-containing signaling molecules operating downstream of theactivated receptor. The purpose of this review is to discuss recent findings on the functional role of ITAMs in antigen and Fc receptor-mediated signal transduction, with a particular emphasis on kinases operating upstream and downstream of the ITAMs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:16:04