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Titolo:
THE EFFECTS OF APOLIPOPROTEIN-E POLYMORPHISM ON THE DISTRIBUTION OF LIPIDS AND LIPOPROTEINS IN THE CHINESE POPULATION
Autore:
KAO JT; TSAI KS; CHANG CJ; HUANG PC;
Indirizzi:
NATL TAIWAN UNIV,COLL MED,SCH MED TECHNOL,CARDIOVASC RES CTR,7 CHUNG SHAN S RD TAIPEI 10764 TAIWAN NATL TAIWAN UNIV HOSP,COLL MED,DEPT LAB MED TAIPEI TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT FAMILY MED TAINAN 70101 TAIWAN NATL TAIWAN UNIV,COLL MED,DEPT BIOCHEM TAIPEI 10764 TAIWAN
Titolo Testata:
Atherosclerosis
fascicolo: 1, volume: 114, anno: 1995,
pagine: 55 - 59
SICI:
0021-9150(1995)114:1<55:TEOAPO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-VARIATION; FREQUENCIES; PHENOTYPES; APOE;
Keywords:
APOLIPOPROTEIN E POLYMORPHISM; SERUM; ISOELECTRIC FOCUSING; TAIWANESE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
J.T. Kao et al., "THE EFFECTS OF APOLIPOPROTEIN-E POLYMORPHISM ON THE DISTRIBUTION OF LIPIDS AND LIPOPROTEINS IN THE CHINESE POPULATION", Atherosclerosis, 114(1), 1995, pp. 55-59

Abstract

The effects of apolipoprotein E (ape E) polymorphism on the distribution of serum levels of total cholesterol (TC), triglyceride (TG), highdensity lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were studied in 546 unrelated Chinese in Taiwan. Byisoelectric focusing and immunoblotting, three common alleles were demonstrated. The frequencies of the epsilon 2, epsilon 3 and epsilon 4 alleles were 0.076, 0.875 and 0.049: respectively. The relative frequency of the epsilon 3 allele was higher than that in Caucasians, whereas the frequency of epsilon 4 was lower in the Chinese population, Individuals with apo E4/4 phenotype had the highest serum TC and LDL-C concentrations, while the lowest levels were associated with apo E2/2 phenotype. There was a trend for individuals carrying the epsilon 2 allele to have a higher HDL-C level, No relationship between apo E phenotype and TG level was observed in this study. These data indicated that agiven apo E allele acted in a relatively similar way in determining individual differences between Chinese and Caucasian populations in serum lipid and lipoprotein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:08:29