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Titolo:
ANTEROGRADE TRACING OF TRIGEMINAL AFFERENT PATHWAYS FROM THE MURINE TOOTH-PULP TO CORTEX USING HERPES-SIMPLEX VIRUS TYPE-1
Autore:
BARNETT EM; EVANS GD; SUN N; PERLMAN S; CASSELL MD;
Indirizzi:
UNIV IOWA,DEPT ANAT IOWA CITY IA 52242 UNIV IOWA,DEPT ANAT IOWA CITY IA 52242 UNIV IOWA,NEUROSCI PROGRAM IOWA CITY IA 52242 UNIV IOWA,COLL DENT IOWA CITY IA 52242 UNIV IOWA,DEPT MICROBIOL IOWA CITY IA 52242 UNIV IOWA,DEPT PEDIAT IOWA CITY IA 52242
Titolo Testata:
The Journal of neuroscience
fascicolo: 4, volume: 15, anno: 1995,
pagine: 2972 - 2984
SICI:
0270-6474(1995)15:4<2972:ATOTAP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATOTOPIC ORGANIZATION; TRANSNEURONAL TRANSPORT; LAMINAR ORGANIZATION; CEREBRAL-CORTEX; RAT MOLAR; PROJECTIONS; NUCLEUS; PAIN; REPRESENTATION; MOUSE;
Keywords:
HERPES SIMPLEX VIRUS TYPE 1; ANTEROGRADE VIRAL TRACING; TRIGEMINAL; NOCICEPTION; TOOTH PULP; INSULAR CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Barnett et al., "ANTEROGRADE TRACING OF TRIGEMINAL AFFERENT PATHWAYS FROM THE MURINE TOOTH-PULP TO CORTEX USING HERPES-SIMPLEX VIRUS TYPE-1", The Journal of neuroscience, 15(4), 1995, pp. 2972-2984

Abstract

Due to its predominantly nociceptive innervation, viral tracing from the tooth pulp provides a potential means for tracing central pain pathways, The neural pathways from the tooth pulp to cortex were determined using in situ hybridization to detect the anterograde transneuronalspread of herpes simplex virus type 1 strain H129 following inoculation into the murine mandibular incisor pulp, Virus first appeared in the brain at day 3 in the dorsomedial region of all three subnuclei of the spinal trigeminal nucleus and the principal sensory nucleus, By days 5-6 virus had spread to the contralateral medial nucleus of the medial geniculate complex, posterior thalamus, and ventroposteromedial thalamus, At days 7-8 virus was detected in laminae IV and Va of the primary somatosensory cortex and lamina IV of the secondary somatosensory cortex in regions previously shown to receive input from the lower jaw, Several mice also showed infection of laminae II/III of the ipsilateral dysgranular insular cortex, along with labeling for virus in the ipsilateral external lateral parabrachial nucleus, posterior thalamus, and posterior basolateral amygdala. Our results are highly consistent with previous tracing and electrophysiological studies utilizing the tooth pulp and with studies implicating the infected structures in nociception, Viral spread appeared to define two separate afferent systemswith infection of structures which have been implicated in the sensory-discriminative aspects of pain, such as the ventroposteromedial thalamus and somatosensory cortex, as well as in the dysgranular insular cortex and related subcortical nuclei which may have a role in the affective-motivational aspects of pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 21:12:58