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Titolo:
PROXIMAL AND DISTAL PULSE PRESSURE AFTER ACUTE ANTIHYPERTENSIVE VASODILATING DRUGS IN WISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS
Autore:
TSOUCARIS D; BENETOS A; LEGRAND M; LONDON GM; SAFAR ME;
Indirizzi:
HOP BROUSSAIS,DEPT INTERNAL MED,SERV MED 1,96 RUE DIDOT F-75014 PARISFRANCE HOP BROUSSAIS,DEPT INTERNAL MED,SERV MED 1 F-75014 PARIS FRANCE HOP BROUSSAIS,INSERM,U337 F-75014 PARIS FRANCE
Titolo Testata:
Journal of hypertension
fascicolo: 2, volume: 13, anno: 1995,
pagine: 243 - 249
SICI:
0263-6352(1995)13:2<243:PADPPA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARDIAC-HYPERTROPHY; CONVERTING ENZYME; WAVE REFLECTIONS; CHRONIC UREMIA; NICARDIPINE; INHIBITION;
Keywords:
HYPERTENSION IN RATS; LARGE ARTERIES; WAVE REFLECTIONS; ANTIHYPERTENSIVE THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D. Tsoucaris et al., "PROXIMAL AND DISTAL PULSE PRESSURE AFTER ACUTE ANTIHYPERTENSIVE VASODILATING DRUGS IN WISTAR-KYOTO AND SPONTANEOUSLY HYPERTENSIVE RATS", Journal of hypertension, 13(2), 1995, pp. 243-249

Abstract

Objective: In a previous study (J Hypertens 1993, 11:135-139) our group showed that in anaesthetized rats, although pulse pressure increased from the proximal (common carotid artery) to the distal (terminal aorta) portion of the aorta in normotensive Wistar-Kyoto (WKY) rats, such a pulse pressure gradient was not observed in spontaneously hypertensive rats (SHR) which had identical values of proximal and distal pulse pressure. The purpose of the present study was to show, in awake SHR, in comparison with awake WKY rats, that the lack of pulse pressure gradient might be functionally reversed after acute administration of vasodilating agents. Methods: The drugs (administered intra-arterially)were an angiotensin converting enzyme inhibitor (perindoprilat; 2 mg/kg), a calcium antagonist (nicardipine; 30 mu g/kg), a peripheral vasodilator (hydralazine; 200 mu g/kg) and placebo (isotonic saline). Blood pressure was evaluated invasively. Results: In untreated rats it wasnoticed that pulse pressure increased physiologically from the proximal to the distal part of the aorta for the same mean arterial pressurein WKY rats, whereas no pulse pressure gradient was observed in SHR. With acute drug administration, marginal modifications were observed in WKY rats, but mean arterial pressure was reduced significantly in SHR (hydralazine> perindoprilat> nicardipine). Proximal pulse pressure was decreased significantly with perindoprilat or nicardipine but was unchanged with hydralazine. Distal pulse pressure was unchanged, exceptfor an increase in the nicardipine-treated group. Heart rate was increased significantly by hydralazine. Conclusion: The results show that,although all of the drugs studied decreased mean arterial pressure inSHR, only the calcium antagonist nicardipine and the angiotensin converting enzyme inhibitor perindoprilat reduced proximal pulse pressure. This dissociation between the effects on mean arterial pressure and proximal and distal pulse pressure can be explained by the preferentialaction of the different antihypertensive agents on large arteries andwave reflections, producing different patterns in the pulsatile component of the heart load.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:22:08