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Titolo:
IN-VITRO ASSESSMENT OF TAXOL FOR HUMAN GLIOBLASTOMA - CHEMOSENSITIVITY AND CELLULAR LOCOMOTION
Autore:
SILBERGELD DL; CHICOINE MR; MADSEN CL;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT NEUROL SURG,CAMPUS BOX 8057,660 S EUCLIDAVE ST LOUIS MO 63110
Titolo Testata:
Anti-cancer drugs
fascicolo: 2, volume: 6, anno: 1995,
pagine: 270 - 276
SICI:
0959-4973(1995)6:2<270:IAOTFH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPIDERMAL GROWTH-FACTOR; HISTOLOGIC FACTORS; TISSUE-CULTURE; GLIOMA-CELLS; HUMAN BRAIN; ASSAY; MULTIFORME; SUPRATENTORIAL; INVITRO; ASTROCYTOMAS;
Keywords:
CELL LOCOMOTION; CHEMOSENSITIVITY; GLIOBLASTOMA; MOTILITY; TAXOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Silbergeld et al., "IN-VITRO ASSESSMENT OF TAXOL FOR HUMAN GLIOBLASTOMA - CHEMOSENSITIVITY AND CELLULAR LOCOMOTION", Anti-cancer drugs, 6(2), 1995, pp. 270-276

Abstract

Although the antineoplastic efficacy of Taxol against a variety of tumors has been established, it has only recently been used for malignant brain tumors. We evaluated in vitro chemosensitivity of glioblastomato Taxol and the affect of Taxol on glioblastoma cell locomotion. Theclonogenic assay was used to evaluate the chemosensitivity of five human glioblastomas and the C6 rat glioma. Cells exposed to Taxol (0-250nM) were suspended in agar in capillary tubes. Following incubation, colonies were counted to determine percent survival. All six cell lines demonstrated sensitivity to Taxol (LD(50) 1 nM to >250 nM). However,even at concentrations exceeding those achievable clinically, all cell lines had surviving cells, indicating a saturation threshold far Taxol cytotoxicity. Cell locomotion was evaluated using the radial dish assay to determine the rate of egress of cells from a region of high cell density to the periphery. Increasing Taxol concentration caused increased locomotion in all six cell lines (p < 0.0001). Although Taxol has significant cytocidal impact, it increases in vitro locomotion of glioblastoma cells. These findings suggest that the clinical use of Taxol for glioblastoma may slow the growth of bulk disease, but may also lead to increased tumor invasion.

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Documento generato il 30/11/20 alle ore 19:49:45