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Titolo:
CHLORIDE TRANSPORT IN THE RAT S1 PROXIMAL TUBULE
Autore:
WONG KR; BERRY CA; COGAN MG;
Indirizzi:
VET AFFAIRS MED CTR,NEPHROL SECT 111J,4150 CLEMENT ST SAN FRANCISCO CA 94121 VET AFFAIRS MED CTR,NEPHROL SECT 111J SAN FRANCISCO CA 94121 UNIV CALIF SAN FRANCISCO,DEPT MED SAN FRANCISCO CA 94121 UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL SAN FRANCISCO CA 94121
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 4, volume: 37, anno: 1995,
pagine: 723 - 729
SICI:
0363-6127(1995)37:4<723:CTITRS>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONVOLUTED TUBULE; ANGIOTENSIN-II; AXIAL HETEROGENEITY; BICARBONATE TRANSPORT; PASSIVE COMPONENTS; WATER TRANSPORT; ABSORPTION; REABSORPTION; KIDNEY; NACL;
Keywords:
S1 PROXIMAL CONVOLUTED TUBULE; WATER TRANSPORT; MUNICH-WISTAR RAT; ANGIOTENSIN II;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K.R. Wong et al., "CHLORIDE TRANSPORT IN THE RAT S1 PROXIMAL TUBULE", American journal of physiology. Renal, fluid and electrolyte physiology, 37(4), 1995, pp. 723-729

Abstract

In vivo microperfusion was used to elucidate the modes and regulationof the powerful chloride transport system resident in the rat early (S1) proximal convoluted tubule (PCT). From a complete, glomerular ultrafiltrate-like perfusate, omission of organic solutes reduced chlorideabsorption by 93 peq . mm(-1). min(-1) (302 +/- 10 to 209 +/- 24, P <0.001). From a high-chloride perfusate (a relatively pure NaCl solution devoid of bicarbonate and organic solutes), luminal addition of theactive transport inhibitor cyanide reduced chloride absorption by 153peq . mm(-1). min(-1) (632 +/- 17 to 479 +/- 9, P < 0.001). Active transport was also estimated directly as 121 +/- 4 peg . mm(-1). min(-1)using a solution in which sodium isethionate isosmotically replaced bicarbonate and organic solutes, preventing development of a chloride gradient. Intravenous angiotensin II caused a stimulation of chloride absorption from a high-chloride perfusate by 55 peg . mm(-1). min(-1) (632 +/- 17 to 687 +/- 14, P < 0.05), which was partially cyanide-sensitive (510 +/- 6 peq . mm(-1). min(-1)). In conclusion, the components of the normal S1 PCT chloride reabsorption (similar to 300 peq . mm(-1). min(-1)) from the glomerular ultrafiltrate consist of the following: active transport (40-50%), which can be regulated by angiotensin II;sodium-coupled organic solute transport (30%); and passive, chloride concentration gradient-driven transport (20-25%).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:01:21