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Titolo:
HYPOFRONTALITY REVISITED - A HIGH-RESOLUTION SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY STUDY IN SCHIZOPHRENIA
Autore:
EBMEIER KP; LAWRIE SM; BLACKWOOD DHR; JOHNSTONE EC; GOODWIN GM;
Indirizzi:
ROYAL EDINBURGH & ASSOCIATED HOSP,MRC,BRAIN METAB UNIT,MORNINGSIDE PKEDINBURGH EH10 5HF MIDLOTHIAN SCOTLAND UNIV EDINBURGH,ROYAL EDINBURGH HOSP,DEPT PSYCHIAT EDINBURGH EH10 5HF MIDLOTHIAN SCOTLAND
Titolo Testata:
Journal of Neurology, Neurosurgery and Psychiatry
fascicolo: 4, volume: 58, anno: 1995,
pagine: 452 - 456
SICI:
0022-3050(1995)58:4<452:HR-AHS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; BRAIN GLUCOSE-METABOLISM; PSYCHIATRIC-DISORDERS; ALZHEIMERS-DISEASE; FRONTAL-LOBE; PET; ABNORMALITIES; SPECT; PATTERNS;
Keywords:
HYPOFRONTALITY; SINGLE PHOTON EMISSION; TOMOGRAPHY; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
K.P. Ebmeier et al., "HYPOFRONTALITY REVISITED - A HIGH-RESOLUTION SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY STUDY IN SCHIZOPHRENIA", Journal of Neurology, Neurosurgery and Psychiatry, 58(4), 1995, pp. 452-456

Abstract

Hypofrontality or reduced activity in the prefrontal cortex, measuredas reduced frontal perfusion or glucose uptake, has gained the statusof an established finding in the medical literature on schizophrenia. Many relevant studies, however, have potential sources of bias, such as small subject numbers, or unreliable performance of activation tasks by the patients during the scanning procedure. Seventy patients withnon-affective and non-organic psychoses were recruited-most qualifying for DSM III-R schizophrenia or schizophreniform psychosis (n = 60)-together with 20 volunteers. They underwent photon emission computed tomography with Tc-99m-exametazime, carried out at rest. Tracer uptake was normalised to the occipital cortex. Group differences in tracer uptake were predicted in anterior regions of interest (prefrontal cortex and mesial frontal/cingulate cortex). Actively psychotic (including schizophrenic) patients not taking any drugs showed increased uptake in the prefrontal cortex. Reduced bracer uptake occurred in the mesial frontal cortex of schizophrenic patients, particularly if they were taking drugs. Relatively increased prefrontal tracer uptake associated with relatively decreased mesial frontal uptake characterised the patients in comparison with the controls. Generalised hypofrontality is, therefore, not a feature of schizophrenic patients at rest whether taking drugs or not.

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Documento generato il 26/01/20 alle ore 16:34:39