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Titolo:
EVOLUTION AT THE TIP AND BASE OF THE X-CHROMOSOME IN AN AFRICAN POPULATION OF DROSOPHILA-MELANOGASTER
Autore:
BEGUN DJ; AQUADRO CF;
Indirizzi:
UNIV CALIF DAVIS,CTR POPULAT BIOL,EVOLUT & ECOL SECT DAVIS CA 95616 CORNELL UNIV,GENET & DEV SECT ITHACA NY 00000
Titolo Testata:
Molecular biology and evolution
fascicolo: 3, volume: 12, anno: 1995,
pagine: 382 - 390
SICI:
0737-4038(1995)12:3<382:EATTAB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACHAETE-SCUTE REGION; RESTRICTION ENDONUCLEASES; LINKAGE DISEQUILIBRIUM; NATURAL-POPULATIONS; GENETIC-VARIATION; DNA POLYMORPHISM; HITCHHIKING; SUPPRESSOR; MUTATIONS; SIMULANS;
Keywords:
DROSOPHILA MELANOGASTER; YELLOW; ACHAETE; SUPPRESSOR OF FORKED; HITCHHIKING EFFECTS; FREQUENCY SPECTRUM; DNA POLYMORPHISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Begun e C.F. Aquadro, "EVOLUTION AT THE TIP AND BASE OF THE X-CHROMOSOME IN AN AFRICAN POPULATION OF DROSOPHILA-MELANOGASTER", Molecular biology and evolution, 12(3), 1995, pp. 382-390

Abstract

Hitchhiking effects of advantageous mutations have been invoked to explain reduced polymorphism in regions of low crossing-over in Drosophila. Besides reducing DNA heterozygosity, hitchhiking effects should produce strong linkage disequilibrium and a frequency spectrum skewed toward an excess of rare polymorphisms (compared to the neutral expectation). We measured DNA polymorphism in a Zimbabwe population of D. melanogaster at three loci, yellow, achaete, and suppressor of forked, located in regions of reduced crossing-over. Similar to previously published surveys of these genomic regions in other populations, we observedlow levels of nucleotide variability. However, the frequency spectrumwas compatible with a neutral model, and there was abundant evidence for recombination in the history of the yellow and ac genes. Thus, some aspects of the data cannot be accounted for by a simple hitchhiking model. An alternative hypothesis, background selection, might be compatible with the observed patterns of linkage disequilibrium and the frequency spectrum. However, this model cannot account for the observed reduction in nucleotide heterozygosity. Thus, there is currently no satisfactory theoretical model for the data from the tip and base of the X chromosome in D. melanogaster.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:55:22