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Titolo:
EFFECT OF THE LEVEL OF ESTRADIOL ON OXYTOCIN-INDUCED PROSTAGLANDIN-F2-ALPHA RELEASE IN THE COW
Autore:
MANN GE; LAMMING GE;
Indirizzi:
UNIV NOTTINGHAM,DEPT PHYSIOL & ENVIRONM SCI LOUGHBOROUGH LE12 5RD LEICS ENGLAND
Titolo Testata:
Journal of Endocrinology
fascicolo: 1, volume: 145, anno: 1995,
pagine: 175 - 180
SICI:
0022-0795(1995)145:1<175:EOTLOE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIAN FOLLICLES; ESTROGEN; HORMONE; DESTRUCTION; SECRETION; DYNAMICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
G.E. Mann e G.E. Lamming, "EFFECT OF THE LEVEL OF ESTRADIOL ON OXYTOCIN-INDUCED PROSTAGLANDIN-F2-ALPHA RELEASE IN THE COW", Journal of Endocrinology, 145(1), 1995, pp. 175-180

Abstract

We have investigated the effects of oestradiol-17 beta on the development of the luteolytic signal (prostaglandin F-2 alpha (PGF(2 alpha)) release to an oxytocin challenge) using a steroid-treated ovariectomised cow model. Long-term ovariectomised cows were pre-treated with progesterone for 14 days followed by oestradiol-17 beta for 2 days to induce oestrus (day 0), and were then treated for a further 16 days with physiological doses of progesterone and oestradiol-17 beta to simulate a luteal phase. On day 11 oestradiol was either withdrawn (low group; n=4), maintained (normal group; n=4) or increased (high group; n=4), generating mean (+/-S.E.M.) plasma concentrations of oestradiol from days 12-16 of 0.9+/-0.1, 23+/-0.4 and 3.7+/-0.2 pg/ml respectively. Basal and oxytocin-stimulated PGF,, secretion was monitored by measuring concentrations of the principal metabolite of PGF(2 alpha), 13,14-dihydro-15-keto PGF(2 alpha) (PGFM), in plasma samples collected before andafter daily i.v. injection of 50 IU oxytocin from days 12-16. Basal PGFM was unaffected by the level of oestradiol treatment. In the normalgroup significant rises in plasma PGFM were seen following oxytocin on days 12, 13 and 14 (P<0.05) as well as days 15 and 16 (P<0.01). In the low group significant elevations in PGFM were only seen on days 15 and 16 (P<0.05), and were smaller (P<0.05) than those seen in the normal group. In the high group two cows showed no elevation in PGFM on any day while in two cows a rise was seen on all days which by day 16 was 84% greater than that seen in the normal group. The results demonstrate that a low level of oestradiol over the second half of the luteal phase leads to a weaker luteolytic signal, while a high level can be stimulatory or inhibitory.

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Documento generato il 11/07/20 alle ore 05:53:40