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Titolo:
PRELIMINARY EVIDENCE FOR AN ASSOCIATION OF A DINUCLEOTIDE REPEAT POLYMORPHISM AT THE MAOA GENE WITH EARLY-ONSET ALCOHOLISM SUBSTANCE ABUSE/
Autore:
VANYUKOV MM; MOSS HB; YU LM; TARTER RE; DEKA R;
Indirizzi:
UNIV PITTSBURGH,SCH MED,WESTERN PSYCHIAT INST & CLIN,CTR EDUC & DRUG ABUSE RES,DEPT PSYCHIAT PITTSBURGH PA 15213 UNIV PITTSBURGH,DEPT HUMAN GENET PITTSBURGH PA 00000 UNIV PITTSBURGH,PITTSBURGH ADOLESCENT ALCOHOL RES CTR PITTSBURGH PA 00000
Titolo Testata:
American journal of medical genetics
fascicolo: 2, volume: 60, anno: 1995,
pagine: 122 - 126
SICI:
0148-7299(1995)60:2<122:PEFAAO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOAMINE-OXIDASE-A; DOPAMINE-D2 RECEPTOR GENE; PLATELET; LOCALIZATION; POPULATION; LOCUS; DNA; AGE;
Keywords:
POLYMERASE CHAIN REACTION; MICROSATELLITE POLYMORPHISM; BEHAVIORAL TRAITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
M.M. Vanyukov et al., "PRELIMINARY EVIDENCE FOR AN ASSOCIATION OF A DINUCLEOTIDE REPEAT POLYMORPHISM AT THE MAOA GENE WITH EARLY-ONSET ALCOHOLISM SUBSTANCE ABUSE/", American journal of medical genetics, 60(2), 1995, pp. 122-126

Abstract

An association between the liability to early onset alcoholism/substance abuse and a recently discovered dinucleotide repeat length polymorphism at the MAOA gene (MAOCA-1) was examined using polymerase chain reaction (PCR), A significant correlation between the presence/absence of the disorder and the length of the MAOCA-1 repeat was found in males, but not females, with ''long'' alleles (repeat length above 115 bp)associated with both increased risk for the disorder and lower age ofonset of substance abuse, These preliminary data suggest that furtherexploration of the relationship between the MAOA gene and behavioral traits in an expanded sample is warranted. (C) 1995 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 14:26:08