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Titolo:
GRAFTS OF GENETICALLY-MODIFIED FIBROBLASTS EXPRESSING NEURAL CELL-ADHESION MOLECULE L1 INTO TRANSECTED SPINAL-CORD OF ADULT-RATS
Autore:
KOBAYASHI S; MIURA M; ASOU H; INOUE HK; OHYE C; UYEMURA K;
Indirizzi:
GUNMA UNIV,SCH MED,DEPT NEUROSURG,3-39-22 SHOWA MACHI MAEBASHI GUMMA 371 JAPAN KEIO UNIV,SCH MED,DEPT PHYSIOL YOKOHAMA JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 188, anno: 1995,
pagine: 191 - 194
SICI:
0304-3940(1995)188:3<191:GOGFEN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
AXONS; REGENERATION; ANTIBODIES; NEURONS; GROWTH; TRANSPLANTATION; GLYCOPROTEINS; MIGRATION; TISSUE; CNS;
Keywords:
GRAFT; REGENERATION; SPINAL CORD; CELL ADHESION MOLECULE; L1; GENETICALLY MODIFIED CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
S. Kobayashi et al., "GRAFTS OF GENETICALLY-MODIFIED FIBROBLASTS EXPRESSING NEURAL CELL-ADHESION MOLECULE L1 INTO TRANSECTED SPINAL-CORD OF ADULT-RATS", Neuroscience letters, 188(3), 1995, pp. 191-194

Abstract

L1, a neural cell adhesion molecule, is known to promote neurite elongation via a hemophilic interaction in vitro. In the present study, fibroblast L cells that were genetically modified to express the L1 molecule were grafted to a lesion of rat spinal cord immediately after hemisection. Grafts drastically promoted regeneration of the axons in theinjured spinal cord 2 weeks after grafting. A number of regenerating axons penetrated the glial scar along the host-graft interface, and elongated into the graft. These results suggest that grafts of genetically modified cells expressing L1 can provide an environment suitable for regeneration of the axons in the injured spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 16:34:01