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Titolo:
CONCURRENT REDUCTION OF INFLAMMATION AND SPINAL FOS-LI NEURONS BY SYSTEMIC DICLOFENAC IN THE RAT
Autore:
BURITOVA J; HONORE P; CHAPMAN V; BESSON JM;
Indirizzi:
INSERM,U161,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Neuroscience letters
fascicolo: 3, volume: 188, anno: 1995,
pagine: 175 - 178
SICI:
0304-3940(1995)188:3<175:CROIAS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HYPERALGESIA; SODIUM; PAIN;
Keywords:
INFLAMMATION; DICLOFENAC; C-FOS; NOCICEPTION; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
J. Buritova et al., "CONCURRENT REDUCTION OF INFLAMMATION AND SPINAL FOS-LI NEURONS BY SYSTEMIC DICLOFENAC IN THE RAT", Neuroscience letters, 188(3), 1995, pp. 175-178

Abstract

Intraplantar carrageenan induced a peripheral inflammation and c-Fos like immunoreactivity (Fos-LI) in the dorsal hem, IA-LS segments, of the rat spinal cord. The total number of control carrageenan evoked Fos-LI neurons was 126 +/- 6 per section, which were predominately located in the superficial and deep laminae (41 +/- 2% and 39 +/- 2% of the total number of Fos-LI neurons per section) of the dorsal horn. Pre-administered diclofenac (3, 6, 9 mg/kg i.v.) dose dependently reduced the number of Fos-LI neurons, with effects being strongest on the deep laminae Fos-LI neurons. The effects of diclofenac (9 mg/kg) on the number of Fos-LI neurons (68 +/- 2% reduction) and inflamed ankle (72 +/- 7% reduction) and paw (49 +/- 6% reduction) diameters, were positivelycorrelated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:20:15